G-quadruplex-binding small molecules ameliorate C9orf72 FTD/ALS pathology in vitro and in vivo

Article

Abstract: Intronic GGGGCC repeat expansions in C9orf72 are the most common known cause of frontotemporal demen

Palabras claves:

amyotrophic lateral sclerosis, C9orf72, frontotemporal dementia, G-quadruplex

Autores:

Abdelkarim S., Balendra R., Boykin D.W., Calvo A., Chio A., Clarke M., Clayton E.L., Farahat A.A., Fratta P., Heslegrave A., Houlden H., Isaacs A.M., Ismail M.A., Javier Gilbert Jaramillo, Konrad M.T., Mitchell J.S., Moens T.G., Neidle S., Niccoli T., Nicoll A.J., Parkinson G., Partridge L., Patani R., Polke J.M., Preza E., Simone R., Stephens C.E., Vo T., Wilson K.M., Wilson W.D., Woodling N.S., Wray S., Zetterberg H.

Fuentes:

scopus