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Accumulation of hypoxia-inducible factor-1α through a novel electrophilic, thiol antioxidant-sensitive mechanism
ArticleAbstract: 15-deoxy-Δ12,14-prostaglandin-J2 (15d-PGJ2) is a peroxisome-activated proliferator receptor-γ (PPARγPalabras claves:15-deoxy-Δ prostaglandin J 12,14 2, Electrophilic, Hypoxia inducible factor, Proximal tubular cells, Reactive oxygen species, Thiol groupsAutores:Arenas I., Castellanos C., Conde I., Lucio-Cazaña J., Manuel Ortiz de Landázuri, Olmos G., Peso L.D.Fuentes:scopusActivation of HIF-prolyl hydroxylases by R59949, an inhibitor of the diacylglycerol kinase
ArticleAbstract: Hypoxia-inducible factors (HIF) are heterodimeric (α/β) transcription factors that play a fundamentaPalabras claves:Autores:Acosta-Iborra B., Aragonés J., Castellanos M.C., Feijóo-Cuaresma M., Manuel Ortiz de Landázuri, Martin-Puig S., Olmos G., Temes E.Fuentes:scopusRole of Iron (II)-2-Oxoglutarate-dependent Dioxygenases in the Generation of Hypoxia-induced Phosphatidic Acid through HIF-1/2 and von Hippel-Lindau-independent Mechanisms
ArticleAbstract: Hypoxia-inducible factors (HIF-1/HIF-2) govern the expression of critical genes for cellular adaptatPalabras claves:Autores:Aragonés J., Jones D.R., Manuel Ortiz de Landázuri, Martin-Puig S., Olmos G., Temes E.Fuentes:scopusThe von Hippel Lindau/hypoxia-inducible factor (HIF) pathway regulates the transcription of the HIF-proline hydroxylase genes in response to low oxygen
ArticleAbstract: Most of the genes induced by hypoxia are regulated by a family of transcription factors termed hypoxPalabras claves:Autores:Castellanos M.C., Cuevas Y., Manuel Ortiz de Landázuri, Martin-Puig S., Olmos G., Peso L.D., Temes E.Fuentes:scopus