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International Journal of Biological Macromolecules(2)
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Snake venom, a natural library of new potential therapeutic molecules: Challenges and current perspectives
ReviewAbstract: Background: Research involving snake venom has gradually surpassed the simple discovery of new molecPalabras claves:Biotechnological applications, New therapeutics, Protein purification, Snake venoms, Toxins, venomicsAutores:Alfonso J.J., Gómez A.F., Grabner F.P., Holanda R.J., Jose Rafael de Almeida, Kayano A.M., Moreira-Dill L.S., Saulo L. Silva, Simões-Silva R., Soares A.M., Sobrinho J.C., Stábeli R.G., Zaqueo K.D., Zuliani J.P.Fuentes:googleorcidscopusStructural, enzymatic and pharmacological profiles of AplTX-II - A basic sPLA2 (D49) isolated from the Agkistrodon piscivorus leucostoma snake venom
ArticleAbstract: A basic sPLA<inf>2</inf> (D49) from the venom of snake Agkistrodon piscivorus leucostoma (AplTX-II)Palabras claves:Agkistrodon piscivorus leuscostoma, Basic sPLA D49 2, Basic sPLA2 D49, molecular modeling, NOBA (4-nitro-3-octanoyloxy benzoic acid)Autores:Fernandes P.A., Jose Rafael de Almeida, Marangoni S., Ramos M.J., Resende L.M., Saulo L. Silva, Soares A.M., Tatiana A. Guaraca-Medina, Viegas M.F.Fuentes:googleorcidscopusSnake venom PLA2s inhibitors isolated from Brazilian plants: synthetic and natural molecules
ArticleAbstract: Ophidian envenomation is an important health problem in Brazil and other South American countries. IPalabras claves:Autores:Carvalho B.M.A., de Azevedo Calderon L., Jose Rafael de Almeida, Marangoni S., Marchi-Salvador D.P., Marcussi S., Martins W., Resende L.M., Santos J.D.L., Saulo L. Silva, Soares A.M., Stábeli R.G., W. Martins, Xavier B.M.Fuentes:googleorcidscopusSnake Venom Peptides and Low Mass Proteins: Molecular Tools and Therapeutic Agents
ArticleAbstract: Snake venoms are natural sources of biologically active molecules that are able to act selectively aPalabras claves:Bradykinin-potentiating peptide, Crotamine, Disintegrin, Natriuretic peptide, Sarafotoxin, Three-finger toxinAutores:Caldeira C.A.S., Carregari V.C., Coutinho-Neto A., de Azevedo Calderon L., Gomes P.A.D.C., Huancahuire-Vega S., Jose Rafael de Almeida, Marangoni S., R. K. Watanabe, Resende L.M., Saulo L. Silva, Soares A.M., Valed N.Fuentes:googleorcidscopusCoaTx-II, a new dimeric Lys49 phospholipase A2 from Crotalus oreganus abyssus snake venom with bactericidal potential: Insights into its structure and biological …
ArticleAbstract: Snake venoms are rich and intriguing sources of biologically-active molecules that act on target celPalabras claves:Antibacterial effect, Crotalus oreganus abyssus, Lys49 phospholipase A 2, Lys49 phospholipase A2, Myotoxicity, Snake venomAutores:David Ramírez, de Azevedo Calderon L., González W., Jose Rafael de Almeida, Lancellotti M., Marangoni S., Ramírez D., Saulo L. Silva, Soares A.M.Fuentes:googleorcidscopusIsolation, structural and functional characterization of a new Lys49 phospholipase A 2 homologue from Bothrops neuwiedi urutu with bactericidal potential
ArticleAbstract: Snake venom is a complex mixture of active compounds consisting of 80–90% proteins and peptides thatPalabras claves:bactericidal activity, Bothrops neuwiedi, Phospholipase A 2, Phospholipase A2, Snake venomAutores:Corrêa E.A., de Azevedo Calderon L., Diniz-Sousa R., Jose Rafael de Almeida, Kayano A.M., Marangoni S., Matos N.B., Resende L.M., Saulo L. Silva, Setúbal S.S., Soares A.M., Zanchi F.B., Zuliani J.P.Fuentes:googleorcidscopusAnti-platelet aggregation activity of two novel acidic Asp49-phospholipases A2 from Bothrops brazili snake venom
ArticleAbstract: Phospholipases A2 (PLA2s) are important enzymes present in snake venoms and are related to a wide spPalabras claves:Acidic phospholipases A 2, Acidic phospholipases A2, Anti-platelet aggregation activity, Bothrops brazili, Snake venomAutores:Alfonso J.J., Fuly A.L., Gómez A.F., Gomez M.C.V., Jose Rafael de Almeida, Kayano A.M., Maria C.Vega Gomez, Moura L.A., Oliveira E., Saulo L. Silva, Simões-Silva R., Soares A.M., Sobrinho J.C., Souza V.R., Zanchi F.B., Zuliani J.P.Fuentes:googleorcidscopusBiochemical and functional studies of ColTx-I, a new myotoxic phospholipase A 2 isolated from Crotalus oreganus lutosus (Great Basin rattlesnake) snake venom
ArticleAbstract: Commonly, phospholipases A2 (PLA2s) play key roles in the pathogenesis of the local tissue damage chPalabras claves:Biological activities, Crotalus oreganus lutosus, Myotoxin, Phospholipase A 2, Phospholipase A2, Snake venomAutores:de Azevedo Calderon L., Jose Rafael de Almeida, Marangoni S., Resende L.M., Ribeiro R.I.M.A., Saulo L. Silva, Silva A.G., Soares A.M., Stábeli R.G.Fuentes:googleorcidscopusCorrigendum to “Exploring and understanding the functional role, and biochemical and structural characteristics of an acidic phospholipase A2, AplTx-I, purified from Agkistrodon piscivorus leucostoma snake venom” [Toxicon 127 (2017) 22–36] (S004101011730003X) (10.1016/j.toxicon.2017.01.002)
OtherAbstract: 2.5.2. Homology modeling and molecular dynamic studies The homology model of AplTx-I were built (usiPalabras claves:Autores:Collaço R.C.O., David Ramírez, de Azevedo Calderon L., González W., Jose Rafael de Almeida, Marangoni S., Ramírez D., Ramos R.S., Resende L.M., Saulo L. Silva, Simioni L.R., Soares A.M.Fuentes:orcidscopusIsolation and characterization of a natriuretic peptide from crotalus oreganus abyssus (grand canyon rattlesnake) and its effects on systemic blood pressure and nitrite levels
ArticleAbstract: Studies on the therapeutic potential of venom peptides have significantly advanced the development oPalabras claves:Bioactive peptides, Crotalus oreganus abyssus, Natriuretic peptide, Nitric oxideAutores:Baldasso P.A., Dias-Junior C.A., Henriques F.A.F.A., Jose Rafael de Almeida, Marangoni S., Martins W., Resende L.M., Resende R.R., Saulo L. Silva, Soares A.M., Taranto A.G., W. MartinsFuentes:orcidscopus