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Preparation of 14,15-secoestra-1,3,5(10)-trien-15-ynes, inhibitors of estradiol dehydrogenase
ArticleAbstract: The conversion of estrone to 14,15-secoestratrien-15-ynes, inactivators of estradiol dehydrogenase fPalabras claves:Autores:Carrell H.L., Covey D.F., Palmer J.O., Richard J. AuchusFuentes:scopusThe enantiomer of progesterone (ent-progesterone) is a competitive inhibitor of human cytochromes P450c17 and P450c21
ArticleAbstract: Human cytochrome P450c17 (17α-hydroxylase, 17,20-lyase) (CYP17) and cytochrome P450c21 (21-hydroxylaPalabras claves:17α-Hydroxylase/17,20-lyase, 21-hydroxylase, CYP17, CYP21, Cytochrome P450c17, Cytochrome P450c21, ent-Progesterone, Enzyme inhibition, molecular dynamics, Type I difference spectrumAutores:Boswell C., Bruce K., Covey D.F., Gupta M.K., Kumar A., Rath N., Richard J. AuchusFuentes:scopus