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A novel biparatopic hybrid antibody-ACE2 fusion that blocks SARS-CoV-2 infection: implications for therapy
ArticleAbstract: In the absence of a proven effective vaccine preventing infection by SARS-CoV-2, or a proven drug toPalabras claves:antibody-ACE2 fusion, Biparatopic, covid-19, neutralizing antibody, SARS-COV-2Autores:Chen C., Chen L., Fu W., Gao W., Huang X., James W.S., Javier Gilbert Jaramillo, Jiang W., Knight M.L., Lee S.M.Y., Liu X., Luo Y., Miao X., Pang T., Rijal P., Song X., Sun J., Tan T.K., Tang Y., Townsend A.R., Tsun A., Wan L., Wang C., Wu F., Xu Y., Yan Y., Yuan Z., Zou Y.Fuentes:scopusInclusion of cGAMP within virus-like particle vaccines enhances their immunogenicity
ArticleAbstract: Cyclic GMP-AMP (cGAMP) is an immunostimulatory molecule produced by cGAS that activates STING. cGAMPPalabras claves:cGAMP, Influenza a virus, SARS-COV-2, type I interferon, viral vaccine vectorAutores:Beveridge R., Borrow P., Bridgeman A., Chauveau L., Drakesmith H., Frost J.N., Javier Gilbert Jaramillo, Knight M.L., Liu X., Partridge T., Pedroza-Pacheco I., Rehwinkel J., Rijal P., Russell R.A., Tan T.K., Townsend A.R.Fuentes:scopusStructures and therapeutic potential of anti-RBD human monoclonal antibodies against SARS-CoV-2
ArticleAbstract: Background: Administration of potent anti-receptor-binding domain (RBD) monoclonal antibodies has bePalabras claves:Antibody cocktail, Antibody-antigen complex, Human monoclonal antibody, In vitro and in vivo function, Receptor-binding domain epitope, SARS-COV-2Autores:Buttigieg K.R., Carroll M.W., Charlton S., Chen C., Chen C.P., Chen X., Cheng S.H., Donat R.F., Duyvesteyn H.M.E., Fry E.E., Ginn H.M., Harding A.C., Huang K.Y.A., James W.S., Javier Gilbert Jaramillo, Lien C.E., Lin M.Y., Lin T.Y., Ma C., Qin L., Ren J., Rijal P., Schimanski L., Stuart D.I., Tan T.K., Townsend A.R., Tree J.A., Zhao Y., Zhou D.Fuentes:scopus