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Molecular modeling of human p450c17 (17α-hydroxylase/ 17,20-lyase) insights into reaction mechanisms and effects of mutations
ArticleAbstract: P450c17 (17α-hydroxylase/17,20-lyase) catalyzes steroid 17α-hydroxylase and 17,20-lyase activities iPalabras claves:Autores:Miller W.L., Richard J. AuchusFuentes:scopusP450c17 mutations R347H and R358Q selectively disrupt 17,20-lyase activity by disrupting interactions with P450 oxidoreductase and cytochrome b<inf>5</inf>
ArticleAbstract: Cytochrome P450c17 catalyzes steroid 17α-hydroxylase and 17,20-lyase activities and hence is a key ePalabras claves:Autores:Geller D.H., Miller W.L., Richard J. AuchusFuentes:scopusMedroxyprogesterone acetate and dexamethasone are competitive inhibitors of different human steroidogenic enzymes
ArticleAbstract: Medroxyprogesterone acetate (MPA), a widely used progestin, can suppress the hypothalamic-pituitary-Palabras claves:Autores:Lee T.C., Miller W.L., Richard J. AuchusFuentes:scopus