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Comparative Neuroregenerative Effects of C-Phycocyanin and IFN-Beta in a Model of Multiple Sclerosis in Mice
ArticleAbstract: Multiple Sclerosis (MS) therapies approved so far are unable to effectively reverse the chronic phasPalabras claves:C-Phycocyanin, EAE, IFN-beta, Multiple Sclerosis, Neuroregeneration, RemyelinationAutores:Alexey Llópiz-Arzuaga, Bergami A., Fernández-Massó J.R., Furlan R., Herrera-Rolo T., Lagumersindez-Denis N., Marín-Prida J., Muzio L., Nazabal-Galvez M., Pentón-Arias E., Pentón-Rol G., Polentarutti N., Raíces-Cruz I., Teixeira M.M., Valenzuela-Silva C.M., Veliz-Rodriguez T.Fuentes:googlescopusC-Phycocyanin ameliorates experimental autoimmune encephalomyelitis and induces regulatory T cells
ArticleAbstract: For decades Experimental Autoimmune Encephalitis (EAE) has remained as an unsurpassed multiple sclerPalabras claves:Central nervous system, Demyelination, Multiple Sclerosis, Neurodegenerative disorder, Regulatory T cellsAutores:Acosta-Medina E.F., Alexey Llópiz-Arzuaga, Alonso-Ramírez R., Cervantes-Llanos M., Falcón-Cama V., Guillén-Nieto G.E., Lagumersindez-Denis N., López-Saura P.A., Marín-Prida J., Martínez-Sánchez G., Pentón-Arias E., Pentón-Rol G., Rodríguez-Jiménez E., Valenzuela-Silva C.M.Fuentes:googlescopusAn anti-CD6 monoclonal antibody (itolizumab) reduces circulating IL-6 in severe COVID-19 elderly patients
ArticleAbstract: Background: Since the COVID-19 outbreak an unprecedented challenge for healthcare systems around thePalabras claves:covid-19, Cytokine release syndrome, IL-6, ItolizumabAutores:Añe-Kouri A.L., Betancourt J., Caballero A., Cepeda M., Chávez E., Filgueira L.M., Herrera C., Hidalgo C.J., Leon K., Lorenzo G., Manso L., Mazorra Z., Ramos M., Saavedra Hernández D., Sánchez N., Tania Crombet, Valenzuela-Silva C.M.Fuentes:scopusCIGB-300, a novel proapoptotic peptide that impairs the CK2 phosphorylation and exhibits anticancer properties both in vitro and in vivo
ArticleAbstract: Protein Kinase CK2 is a serine-threonine kinase frequently deregulated in many human tumors. Here, wPalabras claves:apoptosis, Cancer targeted therapy, Casein kinase 2Autores:Acevedo B.E., Alonso D.F., Ariosa J., Bacardí D.M., Baladron I., Besada-Pérez V., Betancourt L., Castellanos L.R., Cosme K., Cruz M., Díaz A., Falcón-Cama V., Farina H., Garay H.E., Gil J., Gómez D., Gómez R., González L.J., Hernández I., Herrera L., López C., López-Mola E., López-Saura P.A., Marcelo J.L., Mendoza O., Perea-Rodríguez S.E., Perera Y., Puchades Y., Reyes O., Rodriguez A., Sánchez A., Santana A., Serrano J.M., Sigman H., Silva R., Solares M., Thelvia I. Ramos Gómez, Valenzuela-Silva C.M.Fuentes:googlescopusAdjuvant interferon gamma in patients with pulmonary atypical Mycobacteriosis: A randomized, double-blind, placebo-controlled study
ArticleAbstract: Background: High antibiotic resistance is described in atypical Mycobacteriosis, mainly by MycobactePalabras claves:Autores:Bello-Rivero I., Fernández-Olivera N., García-García I., González-Méndez L., Jiménez-Madrigal G., López-Saura P.A., Martínez-Sánchez G., Milanés-Virelles M.T., Rodríguez-Acosta C., Sánchez-de la Osa R.B., Santos-Herrera Y., Thelvia I. Ramos Gómez, Valdés-Quintana M., Valenzuela-Silva C.M.Fuentes:googlescopusErythropoietin in Spinocerebellar Ataxia Type 2: Feasibility and Proof-of-Principle Issues from a Randomized Controlled Study
ArticleAbstract: Background: Several pieces of evidence have shown the neurotrophic effect of erythropoietin (EPO) anPalabras claves:Clinical trial, erythropoietin, human-recombinant erythropoietin, spinocerebellar ataxia type 2Autores:Almaguer Gotay D., Amaro-González D., Aymed-García J., Batista-Nuñez M., Canales-Ochoa N., Carmen Elena Viada, Columbié Ximelis J., Crombet-Ramos T., Estupiñán Rodriguez A., García-García I., García-Rodriguez J.C., Hernández Casaña P., Jiménez-Rodríguez D., Labrada Aguilera P.E., Medrano Montero J., Ortega-Sanchez R., Padrón-Estupiñan M.d.C., Peña Acosta A., Rodríguez-Labrada R., Rodriguez-Obaya T., Santos-Morales O., Silva Ricardo Y., Torres Vega R., Tribin Rivero K., Valenzuela-Silva C.M., Valle Cabrera R., Vazquez-Mojena Y., Velazquez-Perez L.Fuentes:scopusOptimizing CIGB-300 intralesional delivery in locally advanced cervical cancer
ArticleAbstract: Background:We conducted a phase 1 trial in patients with locally advanced cervical cancer by injectiPalabras claves:B23/nucleophosmin, Cervical Cancer, CIGB-300, tumour uptakeAutores:Acevedo B.E., Alonso D.F., Ancízar J.A., Baladron I., Casacó C.A., Coca M.A., García I., Gómez R., González L.J., González Y.M., Hernández I., I. Howland-Álvarez, López-Saura P.A., Martínez Y.M., Molina L., Perea-Rodríguez S.E., Perera A., Perera Y., Prats A., Reyes V., Solares M., Torres L.A., Valenzuela-Silva C.M.Fuentes:scopusIntegrated pharmacokinetic-pharmacodynamic modeling and allometric scaling for optimizing the dosage regimen of the monoclonal ior EGF/r3 antibody
ArticleAbstract: The multiple-dose strategy with the monoclonal ior EGF/r3 antibody, in xenograft bearing nude mice,Palabras claves:Allometric scaling, Dosage regimen, Integrated pharmacokinetic-pharmacodynamic, Monoclonal antibody ior EGF/r3, Survival time, Tumor growth delayAutores:Alonso K., Alvarez D., Beausoleil I., Bécquer M.d.l.A., Castillo R., Duconge J., Fernández-Sánchez E.M., Matheu J., Tania Crombet, Valenzuela-Silva C.M., Vecino G.Fuentes:scopusPharmacokinetic and pharmacodynamic characterization of a novel formulation containing co-formulated interferons alpha-2b and gamma in healthy male volunteers
ArticleAbstract: Background: More potent antitumor activity is desired in Interferon (IFN)-treated cancer patients. TPalabras claves:2'-5' oligoadenylate synthetase, Beta2-microglobulin, interferons, Neopterin, pharmacodynamics, pharmacokineticsAutores:Bello-Rivero I., Campos-Mojena R., Cruz-Ramírez A., Díaz-Machado A., García-Vega Y., González-Delgado C.A., Hernández-González I., I. Howland-Álvarez, López-Saura P.A., Martín-Trujillo A., Pérez-Rodríguez S., Santana-Milián H., Tuero-Iglesias Á.D., Valenzuela-Silva C.M.Fuentes:scopusPhycocyanobilin promotes PC12 cell survival and modulates immune and inflammatory genes and oxidative stress markers in acute cerebral hypoperfusion in rats
ArticleAbstract: Since the inflammatory response and oxidative stress are involved in the stroke cascade, we evaluatePalabras claves:Cerebral hypoperfusion, Gene Expression, inflammation, Oxidative Stress, PC12, phycocyanobilinAutores:Alexey Llópiz-Arzuaga, Cintado-Benítez A., Cruz-Ramírez A., Fernández-Massó J.R., Marín-Prida J., Mendoza-Marí Y., Nazabal-Galvez M., Pardo-Andreu G.L., Pavón-Fuentes N., Pentón-Arias E., Pentón-Rol G., Polentarutti N., Riva F., Roche L.D., Santana S.P., Valenzuela-Silva C.M.Fuentes:googlescopus