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Assessment of the debrisoquin and dextromethorphan phenotyping tests by gaussian mixture distributions analysis
ArticleAbstract: From a sample of 149 unrelated Spaniards, individuals were phenotyped for their ability to hydroxylaPalabras claves:Autores:Adrián LLerena, Avram M., Benitez Rodriguez J., Cobaleda J., Gibbons R., Henthorn T., Krejcie T., Martinez C.Fuentes:scopusAcetylator polymorphism in Parkinson's disease
ArticleAbstract: Acetylator phenotype has been determined using sulphamethazine in 100 patients with Parkinson's disePalabras claves:acetylator phenotype, debrisoquine oxidation, drug polymorphism, Parkinsonism, sulphamethazineAutores:Adrián LLerena, Benitez Rodriguez J., Cobaleda J., Fernandez-Gundin M.J., Jimenez F.J., Ladero J.M., Martinez C., Muñoz J.J.Fuentes:scopusFrequency of S-mephenytoin hydroxylation deficiency in 373 spanish subjects compared to other Caucasian populations
ArticleAbstract: We have investigated the prevalence of poor metabolisers (PM) of S-mephenytoin in 373 unrelated, heaPalabras claves:caucasian, drug metabolism, Mephenytoin, pharmacogenetics, Phenotype, polymorphismAutores:Adrián LLerena, Benitez Rodriguez J., Bertilsson L., Carrillo J.A., Reviriego J., Valdivielso M.J.Fuentes:scopusInfluence of genetic admixture on polymorphisms of drug-metabolizing enzymes: Analyses of mutations on NAT2 and CYP2E1 genes in a mixed Hispanic population
ArticleAbstract: Objectives and study design: The genetic basis of two polymorphisms of drug- and carcinogen-metaboliPalabras claves:Autores:Adrián LLerena, Agúndez J.A.G., Benitez Rodriguez J., Hernandez M., Martínez C., Olivera M., Ramirez R.Fuentes:scopusInterethnic differences in drug metabolism: Influence of genetic and environmental factors on debrisoquine hydroxylation phenotype
Conference ObjectAbstract: Genetic and environmental factors are determinants of the interindividual and interethnic variabilitPalabras claves:CYP2D6, debrisoquine, gender, pharmacogenetics, smokingAutores:Adrián LLerena, Benitez Rodriguez J., Cobaleda J., Martínez C.Fuentes:scopusMolecular heterogeneity at the CYP2D gene locus in Nicaraguans: Impact of gene-flow from Europe
ArticleAbstract:Palabras claves:CYP2D, Cytochrome p450, Gene-flow, Hispanics, NicaraguansAutores:Adrián LLerena, Agúndez J.A.G., Benitez Rodriguez J., Hernandez M., Ramirez R.Fuentes:scopusUse of the mesoridazine/thioridazine ratio as a marker for CYP2D6 enzyme activity
ArticleAbstract: Thioridazine is metabolized in humans by CYP2D6 to mesoridazine, which is an active metabolite. TwoPalabras claves:CYP2D6, High-pressure liquid chromatography, pharmacogenetics, Therapeutic drug monitoring (TDM), ThioridazineAutores:Adrián LLerena, Benitez Rodriguez J., Berecz R., De la Rubia A., Norberto M.Fuentes:scopusOxidative polymorphism of debrisoquine in Parkinson's disease
ArticleAbstract: Oxidative phenotype and metabolic ratio (MR) of debrisoquine (DBQ) have been determined in 87 patienPalabras claves:Autores:Adrián LLerena, Benitez Rodriguez J., Cobaleda J., Jimenez-Jimenez F.J., Ladero J.M., Martínez C., Muñoz J.J., Puerto A.M., Valdivielso M.J.Fuentes:scopusRelationship between personality and debrisoquine hydroxylation capacity: Suggestion of an endogenous neuroactive substrate or product of the cytochrome P4502D6
ArticleAbstract: We administered the Karolinska Scales of Personality to 225 healthy subjects in Spain selected fromPalabras claves:debrisoquine, personality, pharmacogeneticsAutores:Adrián LLerena, Benitez Rodriguez J., Bertilsson L., Cobaleda J., Edman G., Schalling D.Fuentes:scopusReproducibility over Time of Mephenytoin and Debrisoquine Hydroxylation Phenotypes
ArticleAbstract: Mephenytoin and debrisoquine hydroxylation phenotypes were determined twice in 15 Spanish healthy voPalabras claves:Autores:Adrián LLerena, Benitez Rodriguez J., Bertilsson L., Valdivielso M.J.Fuentes:scopus