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Bioconjugate Chemistry(1)
Cancers(1)
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Molecular Therapy - Nucleic Acids(1)
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A combinatorial microRNA therapeutics approach to suppressing non-small cell lung cancer
ArticleAbstract: Targeted cancer therapies, although often effective, have limited utility owing to preexisting primaPalabras claves:Autores:Bader A.G., Chen X., Dysart S., Esteban A. Orellana, Kasinski A.L., Kelnar K., Shimer E., Slack F.J., Stahlhut C., Zhao J.Fuentes:scopusFolamiRs: Ligand-targeted, vehicle-free delivery of microRNAs for the treatment of cancer
ArticleAbstract: MicroRNAs are small RNAs that negatively regulate gene expression posttranscriptionally. Because chaPalabras claves:Autores:Esteban A. Orellana, Kasinski A.L., Low P.S., Lyle L.T., Rangasamy L., Tenneti S.Fuentes:scopusEnhancing MicroRNA Activity through Increased Endosomal Release Mediated by Nigericin
ArticleAbstract: The therapeutic promise of small-RNA therapeutics is limited, not only by the lack of delivery vehicPalabras claves:DELIVERY, endosomal escape, folate, folate-conjugates, ligand, microRNA, miR-34, nigericinAutores:Abdelaal A.M., Esteban A. Orellana, Kasinski A.L., Low P.S., Myoung S., Rangasamy L., Tenneti S.Fuentes:scopusNew Mechanism for Release of Endosomal Contents: Osmotic Lysis via Nigericin-Mediated K<sup>+</sup>/H<sup>+</sup> Exchange
ArticleAbstract: Although peptides, antibodies/antibody fragments, siRNAs, antisense DNAs, enzymes, and aptamers arePalabras claves:Autores:Bandara N.A., Chelvam V., Esteban A. Orellana, Kanduluru A.K., Kasinski A.L., Low P.S., Rangasamy L., Srinivasarao M., You F.Fuentes:scopusNo vehicle, no problem
OtherAbstract:Palabras claves:MiRNA, siRNAAutores:Esteban A. Orellana, Kasinski A.L.Fuentes:scopusIdentification and validation of microRNAs that synergize with miR-34a–a basis for combinatorial microRNA therapeutics
ArticleAbstract: Efforts to search for better treatment options for cancer have been a priority, and due to these effPalabras claves:combinatorial therapeutics, miR-34, miR-34a, miRNA therapeutics, Mirna-34, synergismAutores:Esteban A. Orellana, Kasinski A.L., Li C., Lisevick A.Fuentes:scopusMicrornas in cancer: A historical perspective on the path from discovery to therapy
ReviewAbstract: Recent progress in microRNA (miRNA) therapeutics has been strongly dependent on multiple seminal disPalabras claves:Cáncer, History, microRNA, therapeuticsAutores:Esteban A. Orellana, Kasinski A.L.Fuentes:scopus