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A-ring modified steroidal azoles retaining similar potent and slowly reversible CYP17A1 inhibition as abiraterone
ArticleAbstract: Abiraterone acetate is a potent inhibitor of human cytochrome P450c17 (CYP17A1, 17α-hydroxylase/17,2Palabras claves:abiraterone, androgen, CYP17A1, Cytochrome p450, Enzymology, Prostate cancer, steroidogenesisAutores:Bratoeff E., Garrido M., Peng H.M., Richard J. Auchus, Upadhyay S.K., Yoshimoto F.K.Fuentes:scopusCytochrome b<inf>5</inf> Activates the 17,20-Lyase Activity of Human Cytochrome P450 17A1 by Increasing the Coupling of NADPH Consumption to Androgen Production
ArticleAbstract: Human cytochrome P450 17A1 is required for all androgen biosynthesis and is the target of abirateronPalabras claves:Autores:Im S.C., Pearl N.M., Peng H.M., Rege J., Richard J. Auchus, Turcu A.F., Waskell L.Fuentes:scopusCatalytic modulation of human cytochromes P450 17A1 and P450 11B2 by phospholipid
ArticleAbstract: Unlike most of the drug-metabolizing cytochrome P450s, microsomal P450 17A1 and mitochondrial P450 1Palabras claves:P450 11B2, P450 17A1, phospholipidAutores:Barlow C., Peng H.M., Richard J. AuchusFuentes:scopusCatalytically relevant electrostatic interactions of cytochrome P450c17 (CYP17A1) and cytochrome b<inf>5</inf>
ArticleAbstract: Background: Cytochrome b5 (b5) stimulates the 17,20-lyase activity of cytochrome P450c17 (CYP17A1).Palabras claves:Autores:Anderson S.M., Forsberg S.E., Liu J., Peng H.M., Richard J. Auchus, Tran H.T.Fuentes:scopusAdrenocorticotropin acutely regulates pregnenolone sulfate production by the human adrenal in vivo and in vitro
ArticleAbstract: Background: Dehydroepiandrosterone sulfate (DHEAS) is the most abundant steroid in human circulationPalabras claves:Autores:Nanba A.T., Peng H.M., Rainey W.E., Rege J., Ren J., Richard J. Auchus, Turcu A.F.Fuentes:scopusExpression in escherichia coli, purification, and functional reconstitution of human steroid 5α-reductases
ArticleAbstract: The potent androgen 5α-dihydrotestosterone irreversibly derives from testosterone via the activity oPalabras claves:5α-reductase, androgen, Dihydrotestosterone, prostate, steroidogenesisAutores:Han B., Im S.C., Liu J., Peng H.M., Qiao J., Richard J. Auchus, Valentín-Goyco J.Fuentes:scopusEpoxidation activities of human cytochromes P450c17 and P450c21
ArticleAbstract: Some cytochrome P450 enzymes epoxidize unsaturated substrates, but this activity has not been descriPalabras claves:Autores:Anderson S.M., Peng H.M., Richard J. Auchus, Yoshimoto F.K., Zhang H.Fuentes:scopusErratum: Correction to the action of cytochrome b <inf>5</inf> on CYP2E1 and CYP2C19 activities requires anionic residues D58 and D65(Biochemistry (2013) 52:1 (210?220) (DOI:10.1021/bi301384n))
OtherAbstract:Palabras claves:Autores:Peng H.M., Richard J. AuchusFuentes:scopusHuman cytochrome P450 17A1 structures with metabolites of prostate cancer drug abiraterone reveal substrate-binding plasticity and a second binding site
ArticleAbstract: Abiraterone acetate is a first-line therapy for castration-resistant prostate cancer. This prodrug iPalabras claves:abiraterone, abiraterone metabolism, CYP17A1, Cytochrome p450, Prostate cancer, steroidogenesisAutores:Bart A.G., Peng H.M., Petrunak E.M., Richard J. Auchus, Scott E.E.Fuentes:scopusMaking water-soluble integral membrane proteins in vivo using an amphipathic protein fusion strategy
ArticleAbstract: Integral membrane proteins (IMPs) play crucial roles in all cells and represent attractive pharmacolPalabras claves:Autores:Chen Y., Delisa M.P., Ke A., Liu J., Mizrachi D., Peng H.M., Pollack L., Richard J. Auchus, Turner R.J.Fuentes:scopus