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Biochemistry(4)
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scopus(12)
A-ring modified steroidal azoles retaining similar potent and slowly reversible CYP17A1 inhibition as abiraterone
ArticleAbstract: Abiraterone acetate is a potent inhibitor of human cytochrome P450c17 (CYP17A1, 17α-hydroxylase/17,2Palabras claves:abiraterone, androgen, CYP17A1, Cytochrome p450, Enzymology, Prostate cancer, steroidogenesisAutores:Bratoeff E., Garrido M., Peng H.M., Richard J. Auchus, Upadhyay S.K., Yoshimoto F.K.Fuentes:scopusCytochrome b<inf>5</inf> Activates the 17,20-Lyase Activity of Human Cytochrome P450 17A1 by Increasing the Coupling of NADPH Consumption to Androgen Production
ArticleAbstract: Human cytochrome P450 17A1 is required for all androgen biosynthesis and is the target of abirateronPalabras claves:Autores:Im S.C., Pearl N.M., Peng H.M., Rege J., Richard J. Auchus, Turcu A.F., Waskell L.Fuentes:scopusCatalytic modulation of human cytochromes P450 17A1 and P450 11B2 by phospholipid
ArticleAbstract: Unlike most of the drug-metabolizing cytochrome P450s, microsomal P450 17A1 and mitochondrial P450 1Palabras claves:P450 11B2, P450 17A1, phospholipidAutores:Barlow C., Peng H.M., Richard J. AuchusFuentes:scopusCatalytically relevant electrostatic interactions of cytochrome P450c17 (CYP17A1) and cytochrome b<inf>5</inf>
ArticleAbstract: Background: Cytochrome b5 (b5) stimulates the 17,20-lyase activity of cytochrome P450c17 (CYP17A1).Palabras claves:Autores:Anderson S.M., Forsberg S.E., Liu J., Peng H.M., Richard J. Auchus, Tran H.T.Fuentes:scopusAdrenocorticotropin acutely regulates pregnenolone sulfate production by the human adrenal in vivo and in vitro
ArticleAbstract: Background: Dehydroepiandrosterone sulfate (DHEAS) is the most abundant steroid in human circulationPalabras claves:Autores:Nanba A.T., Peng H.M., Rainey W.E., Rege J., Ren J., Richard J. Auchus, Turcu A.F.Fuentes:scopusEpoxidation activities of human cytochromes P450c17 and P450c21
ArticleAbstract: Some cytochrome P450 enzymes epoxidize unsaturated substrates, but this activity has not been descriPalabras claves:Autores:Anderson S.M., Peng H.M., Richard J. Auchus, Yoshimoto F.K., Zhang H.Fuentes:scopusHuman cytochrome P450 17A1 structures with metabolites of prostate cancer drug abiraterone reveal substrate-binding plasticity and a second binding site
ArticleAbstract: Abiraterone acetate is a first-line therapy for castration-resistant prostate cancer. This prodrug iPalabras claves:abiraterone, abiraterone metabolism, CYP17A1, Cytochrome p450, Prostate cancer, steroidogenesisAutores:Bart A.G., Peng H.M., Petrunak E.M., Richard J. Auchus, Scott E.E.Fuentes:scopusMinor activities and transition state properties of the human steroid hydroxylases cytochromes P450c17 and P450c21, from reactions observed with deuterium-labeled substrates
ArticleAbstract: The steroid hydroxylases CYP17A1 (P450c17, 17-hydroxylase/17,20-lyase) and CYP21A2 (P450c21, 21-hydrPalabras claves:Autores:Matthew S., Peng H.M., Richard J. Auchus, Sharma K.K., Stidd D., Yoshimoto F.K., Yoshimoto J.A., Zhou Y.Fuentes:scopusMolecular Recognition in Mitochondrial Cytochromes P450 That Catalyze the Terminal Steps of Corticosteroid Biosynthesis
ArticleAbstract: The mitochondrial cytochromes P450 11B1 and P450 11B2 are responsible for the final stages of cortisPalabras claves:Autores:Peng H.M., Richard J. AuchusFuentes:scopusTwo surfaces of cytochrome b<inf>5</inf> with major and minor contributions to CYP3A4-catalyzed steroid and nifedipine oxygenation chemistries
ArticleAbstract: Conserved human cytochrome b5 (b5) residues D58 and D65 are critical for interactions with CYP2E1 anPalabras claves:Allostery, CYP3A4, Cytochrome b 5, Cytochrome p450, Drug oxidation, TestosteroneAutores:Peng H.M., Richard J. AuchusFuentes:scopus