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Biochemistry(2)
Archives of Biochemistry and Biophysics(1)
Journal of Biological Chemistry(1)
Journal of Steroid Biochemistry and Molecular Biology(1)
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Bioquímica(4)
Farmacología y terapéutica(4)
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scopus(5)
A-ring modified steroidal azoles retaining similar potent and slowly reversible CYP17A1 inhibition as abiraterone
ArticleAbstract: Abiraterone acetate is a potent inhibitor of human cytochrome P450c17 (CYP17A1, 17α-hydroxylase/17,2Palabras claves:abiraterone, androgen, CYP17A1, Cytochrome p450, Enzymology, Prostate cancer, steroidogenesisAutores:Bratoeff E., Garrido M., Peng H.M., Richard J. Auchus, Upadhyay S.K., Yoshimoto F.K.Fuentes:scopusCatalytically relevant electrostatic interactions of cytochrome P450c17 (CYP17A1) and cytochrome b<inf>5</inf>
ArticleAbstract: Background: Cytochrome b5 (b5) stimulates the 17,20-lyase activity of cytochrome P450c17 (CYP17A1).Palabras claves:Autores:Anderson S.M., Forsberg S.E., Liu J., Peng H.M., Richard J. Auchus, Tran H.T.Fuentes:scopusEpoxidation activities of human cytochromes P450c17 and P450c21
ArticleAbstract: Some cytochrome P450 enzymes epoxidize unsaturated substrates, but this activity has not been descriPalabras claves:Autores:Anderson S.M., Peng H.M., Richard J. Auchus, Yoshimoto F.K., Zhang H.Fuentes:scopusErratum: Correction to the action of cytochrome b <inf>5</inf> on CYP2E1 and CYP2C19 activities requires anionic residues D58 and D65(Biochemistry (2013) 52:1 (210?220) (DOI:10.1021/bi301384n))
OtherAbstract:Palabras claves:Autores:Peng H.M., Richard J. AuchusFuentes:scopusTwo surfaces of cytochrome b<inf>5</inf> with major and minor contributions to CYP3A4-catalyzed steroid and nifedipine oxygenation chemistries
ArticleAbstract: Conserved human cytochrome b5 (b5) residues D58 and D65 are critical for interactions with CYP2E1 anPalabras claves:Allostery, CYP3A4, Cytochrome b 5, Cytochrome p450, Drug oxidation, TestosteroneAutores:Peng H.M., Richard J. AuchusFuentes:scopus