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Catalytically relevant electrostatic interactions of cytochrome P450c17 (CYP17A1) and cytochrome b<inf>5</inf>
ArticleAbstract: Background: Cytochrome b5 (b5) stimulates the 17,20-lyase activity of cytochrome P450c17 (CYP17A1).Palabras claves:Autores:Anderson S.M., Forsberg S.E., Liu J., Peng H.M., Richard J. Auchus, Tran H.T.Fuentes:scopusHuman cytochrome P450 17A1 structures with metabolites of prostate cancer drug abiraterone reveal substrate-binding plasticity and a second binding site
ArticleAbstract: Abiraterone acetate is a first-line therapy for castration-resistant prostate cancer. This prodrug iPalabras claves:abiraterone, abiraterone metabolism, CYP17A1, Cytochrome p450, Prostate cancer, steroidogenesisAutores:Bart A.G., Peng H.M., Petrunak E.M., Richard J. Auchus, Scott E.E.Fuentes:scopus