Mostrando 10 resultados de: 28
Publisher
European Journal of Clinical Pharmacology(5)
Pharmacopsychiatry(3)
Current Drug Targets(2)
Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences(2)
Journal of Psychopharmacology(2)
Área temáticas
Farmacología y terapéutica(23)
Enfermedades(14)
Bioquímica(5)
Medicina y salud(3)
Fisiología humana(2)
Origen
scopus(28)
Clinical implications of CYP2D6 genetic polymorphism during treatment with antipsychotic drugs
ReviewAbstract: CYP2D6 is described as the most relevant enzyme in the metabolism of many antipsychotic drugs. Its cPalabras claves:Antipsychotic drugs, CYP2D6, pharmacogenetics, PharmacogenomicsAutores:Adrián LLerena, Berecz R., Cáceres M.C., Dorado P., Penãs-Lledó E.M.Fuentes:scopusClozapine withdrawal symptoms after change to sertindole in a schizophrenic patient
ArticleAbstract: A 30-year-old male patient with paranoid schizophrenia was on clozapine therapy for more than five yPalabras claves:Autores:Adrián LLerena, Berecz R., De la Rubia A., Degrell I., Glaub T., Kellermann M.Fuentes:scopusAnalysis of diclofenac and its metabolites by high-performance liquid chromatography: Relevance of CYP2C9 genotypes in diclofenac urinary metabolic ratios
ArticleAbstract: In humans, diclofenac is metabolised to 4′-hydroxy (OH), 3′-OH and 5-OH metabolites. The polymorphicPalabras claves:CYP2C9 genotypes, Diclofenac, HydroxydiclofenacAutores:Adrián LLerena, Berecz R., Cáceres M.C., Dorado P.Fuentes:scopusAntibiotic use in 3 European university hospitals
ArticleAbstract: The use of antibiotic drugs was studied in university teaching hospitals in Tartu, Estonia, HuddingePalabras claves:Autores:Adrián LLerena, Berecz R., Dahl M.L., Kiivet R.A., Maimets M., Wettermark B.Fuentes:scopusAntipsychotic drugs and QTc prolongation: The potential role of CYP2D6 genetic polymorphism
ReviewAbstract: Although the most common, and usually serious, side effects of first-generation (or typical) antipsyPalabras claves:Antipsychotic drugs, Cardiac side effects, CYP2D6, drug metabolism, QT interval lengthening, Torsades de pointes-type arrhythmiaAutores:Adrián LLerena, Berecz R., Dorado P., Penãs-Lledó E.M.Fuentes:scopusDetermination of clozapine and its N-desmethyl metabolite by high-performance liquid chromatography with ultraviolet detection
ArticleAbstract: A rapid high-performance liquid chromatographic method has been developed for the simultaneous deterPalabras claves:Clozapine, N-desmethyl clozapineAutores:Adrián LLerena, Berecz R., De la Rubia A., Norberto M.Fuentes:scopusDetermination of debrisoquine and 4-hydroxydebrisoquine by high-performance liquid chromatography: Application to the evaluation of CYP2D6 genotype and debrisoquine metabolic ratio relationship
ArticleAbstract: The drug-metabolizing cytochrome P450 (CYP) enzyme CYP2D6 is involved in the metabolism of several cPalabras claves:CYP2D6, debrisoquine, HPLC, Metabolic ratioAutores:Adrián LLerena, Berecz R., Cáceres M.C., Cobaleda J., Dorado P., González I.Fuentes:scopusDetermination of fluoxetine and norfluoxetine in human plasma by high-performance liquid chromatography with ultraviolet detection in psychiatric patients
ArticleAbstract: A rapid high-performance liquid chromatographic method is described for the simultaneous determinatiPalabras claves:Fluoxetine, NorfluoxetineAutores:Adrián LLerena, Berecz R., Cáceres M.C., De la Rubia A., Dorado P., González A.P., Jesus Norberto M.Fuentes:scopusCYP2C9 gene and susceptibility to major depressive disorder
ArticleAbstract: Alteration of monoaminergic neurotransmission has been implicated in the pathophysiology of mood disPalabras claves:CYP2C9 gene, Depression, SchizophreniaAutores:Adrián LLerena, Berecz R., De la Rubia A., Dorado P., González A.P., Penãs-Lledó E.M.Fuentes:scopusCYP2C9 genotypes and diclofenac metabolism in Spanish healthy volunteers
ArticleAbstract: Objective: This study analyzed the frequency of CYP2C9 variant alleles and evaluated the impact of CPalabras claves:CYP2C9, Diclofenac, GenotypingAutores:Adrián LLerena, Berecz R., Dahl M.L., Dorado P., Norberto M., Yasar U.Fuentes:scopus