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Synthesis and biological evaluation of caracasine acid derivatives
ArticleAbstract: A series of caracasine acid (1) derivatives were synthesized and evaluated for their in vitro cytotoPalabras claves:antibacterial, Antileishmanial, Antitrypanosomal, Caracasine acid, Cytotoxic activity, Ent-kaurane, SynthesisAutores:Alírica Isabel Suárez, Álvarez A., Arocha I., Chavez K., Compagnone R.S., Figarella K., Galindo-Castro I., Marsiccobetre S., Orsini G., Taddei A., Tillett S., Triviño J.Fuentes:scopusThe marine sponge toxin agelasine B increases the intracellular Ca <sup>2+</sup> concentration and induces apoptosis in human breast cancer cells (MCF-7)
ArticleAbstract: Purpose: In search for new drugs derived from natural products for the possible treatment of cancer,Palabras claves:Agelasine B, calcium, Natural products, SERCA, ThapsigarginAutores:Alírica Isabel Suárez, Arvelo F.A., Benaím G., Chirino P., Colman L., Compagnone R.S., de Sanctis J.B., Dipolo R., Felibertt P., Galindo-Castro I., Mayora A., Pimentel A.A., Rojas H., Silva M.L., Sojo F.J.Fuentes:scopusThe natural diterpene ent-16β-17α-dihydroxykaurane down-regulates Bcl-2 by disruption of the Ap-2α/Rb transcription activating complex and induces E2F1 up-regulation in MCF-7 cells
ArticleAbstract: ent-Kauranes are diterpene-type compounds commonly found in most plant species, especially from thePalabras claves:AP-2α/Rb, apoptosis, BCL-2, E2F1, ent-16β-17α-Dihydroxykaurane (DHK), PUMAAutores:Alírica Isabel Suárez, Álvarez A., Arvelo F.A., Compagnone R.S., Galindo-Castro I., Morales A.Fuentes:scopus