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Clinical implications of CYP2D6 genetic polymorphism during treatment with antipsychotic drugs
ReviewAbstract: CYP2D6 is described as the most relevant enzyme in the metabolism of many antipsychotic drugs. Its cPalabras claves:Antipsychotic drugs, CYP2D6, pharmacogenetics, PharmacogenomicsAutores:Adrián LLerena, Berecz R., Cáceres M.C., Dorado P., Penãs-Lledó E.M.Fuentes:scopusAssociation between T102C and A-1438G polymorphisms in the serotonin receptor 2A (5-HT2A) gene and schizophrenia: Relevance for treatment with antipsychotic drugs
ArticleAbstract: Background: An involvement of serotonin receptor 2A (5-HT2A) in the aetiology of schizophrenia has bPalabras claves:A-1438G polymorphism, Risperidone, Schizophrenia, Seretonin 2A receptor, T102C polymorphismAutores:Adrián LLerena, Cáceres M.C., De la Rubia A., Dorado P., Penãs-Lledó E.M.Fuentes:scopusDetermination of fluoxetine and norfluoxetine in human plasma by high-performance liquid chromatography with ultraviolet detection in psychiatric patients
ArticleAbstract: A rapid high-performance liquid chromatographic method is described for the simultaneous determinatiPalabras claves:Fluoxetine, NorfluoxetineAutores:Adrián LLerena, Berecz R., Cáceres M.C., De la Rubia A., Dorado P., González A.P., Jesus Norberto M.Fuentes:scopusIncreased risk for major depression associated with the short allele of the serotonin transporter promoter region (5-HTTLPR-S) and the CYP2C9*3 allele
Conference ObjectAbstract: In the present study, we aimed to analyze the potential relevance of the polymorphism in the promotePalabras claves:5-HTTLPR, CYP2C9, genetic polymorphism, major depression, SerotoninAutores:Adrián LLerena, Cáceres M.C., Cobaleda J., Dorado P., González A.P., Penãs-Lledó E.M.Fuentes:scopusIncreased use of second generation antipsychotic drugs in primary care: Potential relevance for hospitalizations in schizophrenia patients
ArticleAbstract: Aim: To analyze the changes in the prescribing pattern of antipsychotic drugs in primary care in ExtPalabras claves:Antipsychotic, drug utilization, Hospitalization, pharmacoepidemiology, Primary Health Care, SchizophreniaAutores:Adrián LLerena, Cáceres M.C., De la Rubia A., Penãs-Lledó E.M.Fuentes:scopusLow frequency of CYP2D6 poor metabolizers among schizophrenia patients
ArticleAbstract: CYP2D6 has been suggested to be functionally similar to the dopamine transporter. The present studyPalabras claves:Autores:Adrián LLerena, Cáceres M.C., De la Rubia A., Dorado P., Penãs-Lledó E.M.Fuentes:scopusSchizophrenia stigma among medical and nursing undergraduates [2]
OtherAbstract:Palabras claves:Medical Education, Schizophrenia, stigmaAutores:Adrián LLerena, Cáceres M.C., Peas-LLedó E.Fuentes:scopusReproducibility over time of the urinary diclofenac/4′-OH diclofenac ratio among different CYP2C9 genotypes
ArticleAbstract: Diclofenac has been used for the evaluation of CYP2C9 activity in vitro as well as in vivo with varyPalabras claves:CYP2C9, Cytochrome p450, Diclofenac, LOSARTÁNAutores:Adrián LLerena, Berecz R., Cáceres M.C., Conzález I., Dorado P.Fuentes:scopusThe role of cytochrome P450 enzymes in the metabolism of risperidone and its clinical relevance for drug interactions
ReviewAbstract: In the recent years it has been increasingly recognized that pharmacogenetical factors play an imporPalabras claves:CYP2D6, CYP3A4, metabolism, pharmacogenetics, RisperidoneAutores:Adrián LLerena, Berecz R., Cáceres M.C., De la Rubia A., Degrell I., Dorado P.Fuentes:scopus