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Clinical implications of CYP2D6 genetic polymorphism during treatment with antipsychotic drugs
ReviewAbstract: CYP2D6 is described as the most relevant enzyme in the metabolism of many antipsychotic drugs. Its cPalabras claves:Antipsychotic drugs, CYP2D6, pharmacogenetics, PharmacogenomicsAutores:Adrián LLerena, Berecz R., Cáceres M.C., Dorado P., Penãs-Lledó E.M.Fuentes:scopusAnalysis of diclofenac and its metabolites by high-performance liquid chromatography: Relevance of CYP2C9 genotypes in diclofenac urinary metabolic ratios
ArticleAbstract: In humans, diclofenac is metabolised to 4′-hydroxy (OH), 3′-OH and 5-OH metabolites. The polymorphicPalabras claves:CYP2C9 genotypes, Diclofenac, HydroxydiclofenacAutores:Adrián LLerena, Berecz R., Cáceres M.C., Dorado P.Fuentes:scopusDetermination of debrisoquine and 4-hydroxydebrisoquine by high-performance liquid chromatography: Application to the evaluation of CYP2D6 genotype and debrisoquine metabolic ratio relationship
ArticleAbstract: The drug-metabolizing cytochrome P450 (CYP) enzyme CYP2D6 is involved in the metabolism of several cPalabras claves:CYP2D6, debrisoquine, HPLC, Metabolic ratioAutores:Adrián LLerena, Berecz R., Cáceres M.C., Cobaleda J., Dorado P., González I.Fuentes:scopusDetermination of fluoxetine and norfluoxetine in human plasma by high-performance liquid chromatography with ultraviolet detection in psychiatric patients
ArticleAbstract: A rapid high-performance liquid chromatographic method is described for the simultaneous determinatiPalabras claves:Fluoxetine, NorfluoxetineAutores:Adrián LLerena, Berecz R., Cáceres M.C., De la Rubia A., Dorado P., González A.P., Jesus Norberto M.Fuentes:scopusDevelopment of a PCR-based strategy for CYP2D6 genotyping including gene multiplication of worldwide potential use
ArticleAbstract: There is growing consensus on the potential use of pharmacogenetics in clinical practice, and hopesPalabras claves:Autores:Adrián LLerena, Cáceres M.C., Dorado P., Licinio J., Pozo-Guisado E., Wong M.L.Fuentes:scopusIncreased use of second generation antipsychotic drugs in primary care: Potential relevance for hospitalizations in schizophrenia patients
ArticleAbstract: Aim: To analyze the changes in the prescribing pattern of antipsychotic drugs in primary care in ExtPalabras claves:Antipsychotic, drug utilization, Hospitalization, pharmacoepidemiology, Primary Health Care, SchizophreniaAutores:Adrián LLerena, Cáceres M.C., De la Rubia A., Penãs-Lledó E.M.Fuentes:scopusLow frequency of CYP2D6 poor metabolizers among schizophrenia patients
ArticleAbstract: CYP2D6 has been suggested to be functionally similar to the dopamine transporter. The present studyPalabras claves:Autores:Adrián LLerena, Cáceres M.C., De la Rubia A., Dorado P., Penãs-Lledó E.M.Fuentes:scopusRelationship between CYP2C8 genotypes and diclofenac 5-hydroxylation in healthy Spanish volunteers
ArticleAbstract: Purpose: CYP2C8 seems to be involved in diclofenac 5-hydroxylation, while, in vitro, the 4′-hydroxylPalabras claves:CYP2C8, CYP2C9, Diclofenac, Healthy volunteers, SpaniardsAutores:Adrián LLerena, Cáceres M.C., Cavaco I., Dorado P., Piedade R., Ribeiro V.Fuentes:scopusReproducibility over time of the urinary diclofenac/4′-OH diclofenac ratio among different CYP2C9 genotypes
ArticleAbstract: Diclofenac has been used for the evaluation of CYP2C9 activity in vitro as well as in vivo with varyPalabras claves:CYP2C9, Cytochrome p450, Diclofenac, LOSARTÁNAutores:Adrián LLerena, Berecz R., Cáceres M.C., Conzález I., Dorado P.Fuentes:scopusThe role of cytochrome P450 enzymes in the metabolism of risperidone and its clinical relevance for drug interactions
ReviewAbstract: In the recent years it has been increasingly recognized that pharmacogenetical factors play an imporPalabras claves:CYP2D6, CYP3A4, metabolism, pharmacogenetics, RisperidoneAutores:Adrián LLerena, Berecz R., Cáceres M.C., De la Rubia A., Degrell I., Dorado P.Fuentes:scopus