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Article(3)
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European Journal of Clinical Pharmacology(1)
European Journal of Drug Metabolism and Pharmacokinetics(1)
Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences(1)
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Farmacología(3)
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scopus(3)
Analysis of diclofenac and its metabolites by high-performance liquid chromatography: Relevance of CYP2C9 genotypes in diclofenac urinary metabolic ratios
ArticleAbstract: In humans, diclofenac is metabolised to 4′-hydroxy (OH), 3′-OH and 5-OH metabolites. The polymorphicPalabras claves:CYP2C9 genotypes, Diclofenac, HydroxydiclofenacAutores:Adrián LLerena, Berecz R., Cáceres M.C., Dorado P.Fuentes:scopusRelationship between CYP2C8 genotypes and diclofenac 5-hydroxylation in healthy Spanish volunteers
ArticleAbstract: Purpose: CYP2C8 seems to be involved in diclofenac 5-hydroxylation, while, in vitro, the 4′-hydroxylPalabras claves:CYP2C8, CYP2C9, Diclofenac, Healthy volunteers, SpaniardsAutores:Adrián LLerena, Cáceres M.C., Cavaco I., Dorado P., Piedade R., Ribeiro V.Fuentes:scopusReproducibility over time of the urinary diclofenac/4′-OH diclofenac ratio among different CYP2C9 genotypes
ArticleAbstract: Diclofenac has been used for the evaluation of CYP2C9 activity in vitro as well as in vivo with varyPalabras claves:CYP2C9, Cytochrome p450, Diclofenac, LOSARTÁNAutores:Adrián LLerena, Berecz R., Cáceres M.C., Conzález I., Dorado P.Fuentes:scopus