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Association between T102C and A-1438G polymorphisms in the serotonin receptor 2A (5-HT2A) gene and schizophrenia: Relevance for treatment with antipsychotic drugs
ArticleAbstract: Background: An involvement of serotonin receptor 2A (5-HT2A) in the aetiology of schizophrenia has bPalabras claves:A-1438G polymorphism, Risperidone, Schizophrenia, Seretonin 2A receptor, T102C polymorphismAutores:Adrián LLerena, Cáceres M.C., De la Rubia A., Dorado P., Penãs-Lledó E.M.Fuentes:scopusAnalysis of diclofenac and its metabolites by high-performance liquid chromatography: Relevance of CYP2C9 genotypes in diclofenac urinary metabolic ratios
ArticleAbstract: In humans, diclofenac is metabolised to 4′-hydroxy (OH), 3′-OH and 5-OH metabolites. The polymorphicPalabras claves:CYP2C9 genotypes, Diclofenac, HydroxydiclofenacAutores:Adrián LLerena, Berecz R., Cáceres M.C., Dorado P.Fuentes:scopusDetermination of debrisoquine and 4-hydroxydebrisoquine by high-performance liquid chromatography: Application to the evaluation of CYP2D6 genotype and debrisoquine metabolic ratio relationship
ArticleAbstract: The drug-metabolizing cytochrome P450 (CYP) enzyme CYP2D6 is involved in the metabolism of several cPalabras claves:CYP2D6, debrisoquine, HPLC, Metabolic ratioAutores:Adrián LLerena, Berecz R., Cáceres M.C., Cobaleda J., Dorado P., González I.Fuentes:scopusDevelopment of a PCR-based strategy for CYP2D6 genotyping including gene multiplication of worldwide potential use
ArticleAbstract: There is growing consensus on the potential use of pharmacogenetics in clinical practice, and hopesPalabras claves:Autores:Adrián LLerena, Cáceres M.C., Dorado P., Licinio J., Pozo-Guisado E., Wong M.L.Fuentes:scopusIncreased risk for major depression associated with the short allele of the serotonin transporter promoter region (5-HTTLPR-S) and the CYP2C9*3 allele
Conference ObjectAbstract: In the present study, we aimed to analyze the potential relevance of the polymorphism in the promotePalabras claves:5-HTTLPR, CYP2C9, genetic polymorphism, major depression, SerotoninAutores:Adrián LLerena, Cáceres M.C., Cobaleda J., Dorado P., González A.P., Penãs-Lledó E.M.Fuentes:scopusRelationship between CYP2C8 genotypes and diclofenac 5-hydroxylation in healthy Spanish volunteers
ArticleAbstract: Purpose: CYP2C8 seems to be involved in diclofenac 5-hydroxylation, while, in vitro, the 4′-hydroxylPalabras claves:CYP2C8, CYP2C9, Diclofenac, Healthy volunteers, SpaniardsAutores:Adrián LLerena, Cáceres M.C., Cavaco I., Dorado P., Piedade R., Ribeiro V.Fuentes:scopusReproducibility over time of the urinary diclofenac/4′-OH diclofenac ratio among different CYP2C9 genotypes
ArticleAbstract: Diclofenac has been used for the evaluation of CYP2C9 activity in vitro as well as in vivo with varyPalabras claves:CYP2C9, Cytochrome p450, Diclofenac, LOSARTÁNAutores:Adrián LLerena, Berecz R., Cáceres M.C., Conzález I., Dorado P.Fuentes:scopusLow frequency of CYP2D6 poor metabolizers among schizophrenia patients
ArticleAbstract: CYP2D6 has been suggested to be functionally similar to the dopamine transporter. The present studyPalabras claves:Autores:Adrián LLerena, Cáceres M.C., De la Rubia A., Dorado P., Penãs-Lledó E.M.Fuentes:scopus