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2-Amino diphenylsulfides as new inhibitors of trypanothione reductase
ArticleAbstract: Trypanothione reductase (TR) is the primary enzyme responsible for the reduction of trypanothione, tPalabras claves:2-Amino-diphenylsulfide, enzyme inhibitors, TRYPANOSOMA CRUZI, Trypanosomatidae, Trypanothione reductaseAutores:Aumercier M., Bethegnies G., Luyckx M., Moutiez M., Ouaissi A., Rodolfo Fernández-Gómez, Sergheraert C., Tartar A.Fuentes:scopusA novel and basic mechanism of immunosuppression in Chagas' disease: Trypanosoma cruzi releases in vitro and in vivo a protein which induces T cell unresponsiveness through specific interaction with cysteine and glutathione
ArticleAbstract:Palabras claves:Cysteine, Glutathione, Immunosuppression, Tc52 protein, TRYPANOSOMA CRUZIAutores:Angel Guevara-Espinoza, Chabé F., Gomez-Corvera R., Ouaissi A., Taibi A.Fuentes:googlescopusHigh infection rates of Triatoma dimidiata are associated with low levels of Trypanosoma cruzi seroprevalence in Pedro Carbo, Ecuador. Use of a TC24 gene-based PCR approach
ArticleAbstract: In control programs for vectorial transmission of Chagas' disease, conventional microscopic procedurPalabras claves:Chagas' disease, ECUADOR, Polymerase Chain Reaction, Triatoma dimidiata, TRYPANOSOMA CRUZI, Vectorial capacityAutores:Ángel Gustavo Guevara, Bowen C., Córdova X., Eduardo A. Gomez-Landires, Garzón E., Ouaissi A.Fuentes:scopusMolecular and immunological characterization of a Trypanosoma cruzi protein homologous to mammalian elongation factor 1 gamma
ArticleAbstract: In previous studies, we reported the characterization of three Trypanosoma cruzi proteins with molecPalabras claves:EF-1γ, elongation factor, Glutathione S-transferase, TRYPANOSOMA CRUZIAutores:Billaut-Mulot O., Capron A., Loyens M., Ouaissi A., Plumas-Marty B., Pommier V., Rodolfo Fernández-Gómez, Schoneck R., Taibi A.Fuentes:scopusPhenotype of recombinant Trypanosoma cruzi which overexpress elongation factor 1-γ: Possible involvement of EF-1γ GST-like domain in the resistance to clomipramine
ArticleAbstract: In previous studies, molecular and immunological approaches have been used to characterize the TrypaPalabras claves:Drug resistance, Elongation factor 1γ, Transfection, TRYPANOSOMA CRUZIAutores:Billaut-Mulot O., Ouaissi A., Rodolfo Fernández-GómezFuentes:scopusN-Acetylcysteine and glutathione modulate the behaviour of Trypanosoma cruzi experimental infection
ArticleAbstract:Palabras claves:Glutathione monoester, Immunoregulation, N-acetylcysteine, TRYPANOSOMA CRUZIAutores:Ángel Gustavo Guevara, Borges M., Da Silva A., Guilvard E., Ouaissi A.Fuentes:scopusTrypanosoma cruzi carrying a targeted deletion of a Tc52 protein-encoding allele elicits attenuated Chagas' disease in mice
ArticleAbstract: The intracellular protozoan parasite Trypanosoma cruzi is the etiological agent of Chagas' disease.Palabras claves:IFN-γ, IL-2, pathology, Tc52 mutant +/-, TRYPANOSOMA CRUZIAutores:Ángel Gustavo Guevara, Borges M., Bosseno M.F., Breniere S.F., Da Silva A., Garzón E., Guilvard E., Meirelles M., Nacife V., Ouaissi A.Fuentes:scopusTrypanosoma cruzi isoenzyme variability in Ecuador: First observation of zymodeme III genotypes in chronic chagasic patients
ArticleAbstract: We have analysed by multilocus enzyme electrophoresis (MLEE) at 21 genetic loci 10 Trypanosoma cruziPalabras claves:Chagas disease, ECUADOR, Isoenzyme profiles, Triatoma dimidiata, TRYPANOSOMA CRUZI, ZymodemesAutores:Ángel Gustavo Guevara, Barnabe C., Bowen C., Córdova X., Eduardo A. Gomez-Landires, Garzón E., Ouaissi A., Paredes W., Tibayrenc M.Fuentes:scopus