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2-Amino diphenylsulfides as new inhibitors of trypanothione reductase
ArticleAbstract: Trypanothione reductase (TR) is the primary enzyme responsible for the reduction of trypanothione, tPalabras claves:2-Amino-diphenylsulfide, enzyme inhibitors, TRYPANOSOMA CRUZI, Trypanosomatidae, Trypanothione reductaseAutores:Aumercier M., Bethegnies G., Luyckx M., Moutiez M., Ouaissi A., Rodolfo Fernández-Gómez, Sergheraert C., Tartar A.Fuentes:scopusA novel and basic mechanism of immunosuppression in Chagas' disease: Trypanosoma cruzi releases in vitro and in vivo a protein which induces T cell unresponsiveness through specific interaction with cysteine and glutathione
ArticleAbstract:Palabras claves:Cysteine, Glutathione, Immunosuppression, Tc52 protein, TRYPANOSOMA CRUZIAutores:Angel Guevara-Espinoza, Chabé F., Gomez-Corvera R., Ouaissi A., Taibi A.Fuentes:googlescopusMolecular and immunological characterization of a Trypanosoma cruzi protein homologous to mammalian elongation factor 1 gamma
ArticleAbstract: In previous studies, we reported the characterization of three Trypanosoma cruzi proteins with molecPalabras claves:EF-1γ, elongation factor, Glutathione S-transferase, TRYPANOSOMA CRUZIAutores:Billaut-Mulot O., Capron A., Loyens M., Ouaissi A., Plumas-Marty B., Pommier V., Rodolfo Fernández-Gómez, Schoneck R., Taibi A.Fuentes:scopusPhenotype of recombinant Trypanosoma cruzi which overexpress elongation factor 1-γ: Possible involvement of EF-1γ GST-like domain in the resistance to clomipramine
ArticleAbstract: In previous studies, molecular and immunological approaches have been used to characterize the TrypaPalabras claves:Drug resistance, Elongation factor 1γ, Transfection, TRYPANOSOMA CRUZIAutores:Billaut-Mulot O., Ouaissi A., Rodolfo Fernández-GómezFuentes:scopusSevere digestive pathology associated with chronic Chagas' disease in Ecuador: report of two cases.
ReviewAbstract: DNA extracted from peripheral blood of two Ecuadorian patients showing severe digestive pathology waPalabras claves:Autores:Ángel Gustavo Guevara, Eras J., Guderian R.H., Ouaissi A., Philip John Cooper, Recalde M., Vinueza L.Fuentes:scopusTrypanosoma cruzi : A 6 X histidine-fused Tc24 protein useful for the serological diagnosis of Chagas' disease
ArticleAbstract: A Trypanosoma cruzi protein containing six histidine residues at its N-terminal sequence (6 X his-TcPalabras claves:Autores:Ángel Gustavo Guevara, Billaut-Mulot O., Ouaissi A., Taibi A.Fuentes:scopusTrypanosoma cruzi carrying a targeted deletion of a Tc52 protein-encoding allele elicits attenuated Chagas' disease in mice
ArticleAbstract: The intracellular protozoan parasite Trypanosoma cruzi is the etiological agent of Chagas' disease.Palabras claves:IFN-γ, IL-2, pathology, Tc52 mutant +/-, TRYPANOSOMA CRUZIAutores:Ángel Gustavo Guevara, Borges M., Bosseno M.F., Breniere S.F., Da Silva A., Garzón E., Guilvard E., Meirelles M., Nacife V., Ouaissi A.Fuentes:scopusTrypanosoma cruzi elongation factor 1-α: Nuclear localization in parasites undergoing apoptosis
ArticleAbstract: The cloning and sequencing of the gene coding for Trypanosoma cruzi elongation factor 1α (TcEF-1α) wPalabras claves:Antibodies to Artemia salina EF-1α, Fusion protein, Genomic library, Immunodetection, Programmed cell deathAutores:Billaut-Mulot O., Loyens M., Ouaissi A., Rodolfo Fernández-GómezFuentes:scopusTrypanosoma cruzi-induced host immune system dysfunction: A rationale for parasite immunosuppressive factor(s) encoding gene targeting
ReviewAbstract: An intense suppression of T cell proliferation to mitogens and toantigens is observed in a large numPalabras claves:Autores:Ángel Gustavo Guevara, Borges M., Da Silva A., Guilvard E., Ouaissi A.Fuentes:scopusTrypanosoma cruzi: Analysis of cellular and humoral response against a protective recombinant antigen during experimental Chagas' disease
ArticleAbstract: In previous studies we have shown the protective value of T. cruzi excretory/secretory antigens (ESAPalabras claves:Cellular immunity, Chagas' disesae, Humoral immunity, T cruzi, Tc24Autores:Angel Guevara-Espinoza, Ouaissi A., Taibi A.Fuentes:scopus