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A novel and basic mechanism of immunosuppression in Chagas' disease: Trypanosoma cruzi releases in vitro and in vivo a protein which induces T cell unresponsiveness through specific interaction with cysteine and glutathione
ArticleAbstract:Palabras claves:Cysteine, Glutathione, Immunosuppression, Tc52 protein, TRYPANOSOMA CRUZIAutores:Angel Guevara-Espinoza, Chabé F., Gomez-Corvera R., Ouaissi A., Taibi A.Fuentes:googlescopusHigh infection rates of Triatoma dimidiata are associated with low levels of Trypanosoma cruzi seroprevalence in Pedro Carbo, Ecuador. Use of a TC24 gene-based PCR approach
ArticleAbstract: In control programs for vectorial transmission of Chagas' disease, conventional microscopic procedurPalabras claves:Chagas' disease, ECUADOR, Polymerase Chain Reaction, Triatoma dimidiata, TRYPANOSOMA CRUZI, Vectorial capacityAutores:Ángel Gustavo Guevara, Bowen C., Córdova X., Eduardo A. Gomez-Landires, Garzón E., Ouaissi A.Fuentes:scopusErratum: Improved specificity of Trypanosoma cruzi identification by polymerase chain reaction using an oligonucleotide derived from the amino-terminal sequence of a Tc24 protein (Parasitology (1995) 11, (581-590))
OtherAbstract:Palabras claves:Autores:Angel Guevara-Espinoza, Ouaissi A., Schoneck R., Taibi A., Yahiaoui B.Fuentes:googlescopusN-Acetylcysteine and glutathione modulate the behaviour of Trypanosoma cruzi experimental infection
ArticleAbstract:Palabras claves:Glutathione monoester, Immunoregulation, N-acetylcysteine, TRYPANOSOMA CRUZIAutores:Ángel Gustavo Guevara, Borges M., Da Silva A., Guilvard E., Ouaissi A.Fuentes:scopusTrypanosoma cruzi carrying a targeted deletion of a Tc52 protein-encoding allele elicits attenuated Chagas' disease in mice
ArticleAbstract: The intracellular protozoan parasite Trypanosoma cruzi is the etiological agent of Chagas' disease.Palabras claves:IFN-γ, IL-2, pathology, Tc52 mutant +/-, TRYPANOSOMA CRUZIAutores:Ángel Gustavo Guevara, Borges M., Bosseno M.F., Breniere S.F., Da Silva A., Garzón E., Guilvard E., Meirelles M., Nacife V., Ouaissi A.Fuentes:scopusTrypanosoma cruzi isoenzyme variability in Ecuador: First observation of zymodeme III genotypes in chronic chagasic patients
ArticleAbstract: We have analysed by multilocus enzyme electrophoresis (MLEE) at 21 genetic loci 10 Trypanosoma cruziPalabras claves:Chagas disease, ECUADOR, Isoenzyme profiles, Triatoma dimidiata, TRYPANOSOMA CRUZI, ZymodemesAutores:Ángel Gustavo Guevara, Barnabe C., Bowen C., Córdova X., Eduardo A. Gomez-Landires, Garzón E., Ouaissi A., Paredes W., Tibayrenc M.Fuentes:scopusTrypanosoma cruzi-induced host immune system dysfunction: A rationale for parasite immunosuppressive factor(s) encoding gene targeting
ReviewAbstract: An intense suppression of T cell proliferation to mitogens and toantigens is observed in a large numPalabras claves:Autores:Ángel Gustavo Guevara, Borges M., Da Silva A., Guilvard E., Ouaissi A.Fuentes:scopusTrypanosoma cruzi: Analysis of cellular and humoral response against a protective recombinant antigen during experimental Chagas' disease
ArticleAbstract: In previous studies we have shown the protective value of T. cruzi excretory/secretory antigens (ESAPalabras claves:Cellular immunity, Chagas' disesae, Humoral immunity, T cruzi, Tc24Autores:Angel Guevara-Espinoza, Ouaissi A., Taibi A.Fuentes:scopusTrypanosoma cruzi: Immunity-induced in mice and rats by trypomastigote excretory-secretory antigens and identification of a peptide sequence containing a T cell epitope with protective activity
ArticleAbstract: In the present study, we investigate the immunoprotective properties of trypomastigote excretory-secPalabras claves:Autores:Aguirre T., Angel Guevara-Espinoza, Bossus M., Capron A., Gras-Masse H., Loyens M., Ouaissi A., Pessoa H., Piras R., Plumas-Marty B., Schoneck R., Taibi A., Tartar A.Fuentes:googlescopusTrypanosoma cruzi: Tc52 released protein-induced increased expression of nitric oxide synthase and nitric oxide production by macrophages
ArticleAbstract: Trypanosoma cruzi target molecules that might regulate the host immune responses have not yet been fPalabras claves:Autores:Esteban S., Gomez-Corvera R., Ouaissi A., Rodolfo Fernández-Gómez, Zoulika K.Fuentes:scopus