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Astemizole Synergizes Calcitriol Antiproliferative Activity by Inhibiting CYP24A1 and Upregulating VDR: A Novel Approach for Breast Cancer Therapy
ArticleAbstract: Background: Calcitriol antiproliferative effects include inhibition of the oncogenic ether-à-go-go-1Palabras claves:Autores:Avila-Chávez E., David B., Díaz L., Gamboa-Dominguez A., García-Becerra R., García-Quiroz J., Halhali A., Javier Camacho, Larrea F., Medina-Franco H., Ordaz-Rosado D., Rivas-Suárez M., Rodríguez P., Santos-Martínez N.Fuentes:scopusCalcitriol restores antiestrogen responsiveness in estrogen receptor negative breast cancer cells: A potential new therapeutic approach
ArticleAbstract: Background: Approximately 30% of breast tumors do not express the estrogen receptor (ER) α, which isPalabras claves:Breast Cancer, Calcitriol, Estrogen receptor, Hormonal therapy, VDRAutores:Avila-Chávez E., David B., Díaz L., Esparza-López J., García-Becerra R., García-Quiroz J., Halhali A., Ibarra-Sánchez M., Javier Camacho, Larrea F., Medina-Franco H., Ordaz-Rosado D., Santos-Martínez N.Fuentes:scopusIn vivo dual targeting of the oncogenic ether-à-go-go-1 potassium channel by calcitriol and astemizole results in enhanced antineoplastic effects in breast tumors
ArticleAbstract: Background: The oncogenic ether-à-go-go-1 potassium channel (EAG1) activity and expression are necesPalabras claves:Breast Cancer, Eag1, Ki-67, Targeted therapy, vitamin D, Vitamin D receptorAutores:Avila-Chávez E., David B., Díaz L., Esparza-López J., Gamboa-Dominguez A., García-Becerra R., García-Quiroz J., Halhali A., Ibarra-Sánchez M., Javier Camacho, Larrea F., Ordaz-Rosado D., Santos-Martínez N., Villanueva O.Fuentes:scopus