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A single dose of pirfenidone attenuates neuronal loss and reduces lipid peroxidation after kainic acid-induced excitotoxicity in the pubescent rat hippocampus
ArticleAbstract: Systemic administration of kainic acid (KA) in rodents triggers limbic seizures following selectivePalabras claves:4-Hydroxynonenal (4-HNE), Kainic Acid Model, Neurodegeneration, neuroprotection, PirfenidoneAutores:Antoni Camins, Armendáriz-Borunda J., Bañuelos-Pineda J., Castro-Torres R.D., Chaparro-Huerta V., Flores-Soto M.E., Orozco-Suárez S.A., Zárate C.B.Fuentes:scopusHIF-1α expression in the hippocampus and peripheral macrophages after glutamate-induced excitotoxicity
ArticleAbstract: Hypoxia-inducible factor-1 alpha (HIF-1α) is a master transcription factor that regulates the responPalabras claves:EPO, Excitotoxicity, HIF-1 alpha, hippocampus, Macrophages, VEGFAutores:Antoni Camins, Armendáriz-Borunda J., Chaparro-Huerta V., Flores-Soto M.E., Gudiño-Cabrera G., Pallás M., Rivera-Cervantes M.C., Torres-Mendoza B.M., Vázquez-Valls E., Zárate C.B.Fuentes:scopusPirfenidone Attenuates Microglial Reactivity and Reduces Inducible Nitric Oxide Synthase mRNA Expression After Kainic Acid-Mediated Excitotoxicity in Pubescent Rat Hippocampus
ArticleAbstract: Excitotoxicity and neuroinflammation are strongly linked to the progressions of neurodegenerative diPalabras claves:cytokines, iNOS, Kainic acid, Microglial reactivity, PirfenidoneAutores:Antoni Camins, Armendáriz-Borunda J., Castro-Torres R.D., Chaparro-Huerta V., Flores-Soto M.E., Jave-Suárez L., Mena-Munguía S., Zárate C.B.Fuentes:scopus