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A single dose of pirfenidone attenuates neuronal loss and reduces lipid peroxidation after kainic acid-induced excitotoxicity in the pubescent rat hippocampus
ArticleAbstract: Systemic administration of kainic acid (KA) in rodents triggers limbic seizures following selectivePalabras claves:4-Hydroxynonenal (4-HNE), Kainic Acid Model, Neurodegeneration, neuroprotection, PirfenidoneAutores:Antoni Camins, Armendáriz-Borunda J., Bañuelos-Pineda J., Castro-Torres R.D., Chaparro-Huerta V., Flores-Soto M.E., Orozco-Suárez S.A., Zárate C.B.Fuentes:scopusPirfenidone Attenuates Microglial Reactivity and Reduces Inducible Nitric Oxide Synthase mRNA Expression After Kainic Acid-Mediated Excitotoxicity in Pubescent Rat Hippocampus
ArticleAbstract: Excitotoxicity and neuroinflammation are strongly linked to the progressions of neurodegenerative diPalabras claves:cytokines, iNOS, Kainic acid, Microglial reactivity, PirfenidoneAutores:Antoni Camins, Armendáriz-Borunda J., Castro-Torres R.D., Chaparro-Huerta V., Flores-Soto M.E., Jave-Suárez L., Mena-Munguía S., Zárate C.B.Fuentes:scopus