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scopus(6)
5α-reduced C<inf>21</inf> steroids are substrates for human cytochrome P450c17
ArticleAbstract: The 5α-reduction of testosterone in target tissues is a key step in androgen physiology; however, 5αPalabras claves:17-hydroxylase/17,20-lyase, 3α-Hydroxysteroid dehydrogenase, 5α-reductase, Allopregnanolone, Androstanediol, CYP17, Cytochrome b 5, Dihydrotestosterone, P450c17, Sexual differentiationAutores:Gupta M.K., Guryev O.L., Richard J. AuchusFuentes:scopusEvidence that androgens are the primary steroids produced by Xenopus laevis ovaries and may signal through the classical androgen receptor to promote oocyte maturation
ArticleAbstract: Steroid-induced maturation of Xenopus oocytes has long served as a model for studying meiosis. ProgePalabras claves:Autores:Cole L.M., Gupta M.K., Hammes S.R., Kwist K.W., Lutz L.B., Richard J. AuchusFuentes:scopusPitfalls in characterizing P450c17 mutations associated with isolated 17,20-lyase deficiency
ArticleAbstract: The cytochrome P450c17 enzyme system performs both the 17α-hydroxylase and 17,20-lyase reactions inPalabras claves:Autores:Geller D.H., Gupta M.K., Richard J. AuchusFuentes:scopusTowards a unifying mechanism for CYP17 mutations that cause isolated 17, 20-lyase deficiency
Conference ObjectAbstract: Cytochrome P450c17 (CYP17) is a single hemoprotein that catalyzes both the 17x-hydroxylase and 17, 2Palabras claves:Autores:Gupta M.K., Richard J. AuchusFuentes:scopusWhy human cytochrome P450c21 is a progesterone 21-hydroxylase
ArticleAbstract: Human cytochrome P450c21 (steroid 21-hydroxylase, CYP21A2) catalyzes the 21-hydroxylation of progestPalabras claves:Autores:Dwyer C., Gupta M.K., Mizrachi D., Richard J. Auchus, Sharma K.K., Wang Z., Xu K.Fuentes:scopusThe enantiomer of progesterone (ent-progesterone) is a competitive inhibitor of human cytochromes P450c17 and P450c21
ArticleAbstract: Human cytochrome P450c17 (17α-hydroxylase, 17,20-lyase) (CYP17) and cytochrome P450c21 (21-hydroxylaPalabras claves:17α-Hydroxylase/17,20-lyase, 21-hydroxylase, CYP17, CYP21, Cytochrome P450c17, Cytochrome P450c21, ent-Progesterone, Enzyme inhibition, molecular dynamics, Type I difference spectrumAutores:Boswell C., Bruce K., Covey D.F., Gupta M.K., Kumar A., Rath N., Richard J. AuchusFuentes:scopus