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An overview of investigational antiapoptotic drugs with potential application for the treatment of neurodegenerative disorders
ReviewAbstract: Importance of the field: The increase in life expectancy in developed countries has given rise to sePalabras claves:Alzheimer's disease, apoptosis, Neuroprotective drugs, Parkinson's DiseaseAutores:Antoni Camins, Folch J., Junyent F., Pallás M., Sureda F.X., Verdaguer E., Zárate C.B.Fuentes:scopusAntiapoptotic drugs: A therapautic strategy for the prevention of neurodegenerative diseases
ReviewAbstract: The purpose of this review is to discuss potential pathways involved in the pathogenesis of neurodegPalabras claves:Alzheimer's disease, apoptosis, Cyclin-dependent kinases, Glutamate receptors, Neuronal cell death, Neuroprotective drugs. apoptosis, Parkinson's DiseaseAutores:Antoni Camins, Auladell C., Canudas A.M., Folch J., Junyent F., Pallás M., Pelegrí Gabalda C., Sureda F.X., Verdaguer E., Vilaplana J., Zárate C.B.Fuentes:scopusAntiapoptotic effects of roscovitine in cerebellar granule cells deprived of serum and potassium: A cell cycle-related mechanism
ArticleAbstract: Neuronal apoptosis may be partly due to inappropriate control of the cell cycle. We used serum depriPalabras claves:apoptosis, Caspase-3, cell cycle, cyclin, E2F-1, RoscovitineAutores:Antoni Camins, Camarasa J., Canudas A.M., Escubedo E., Jiménez A., Jordá E.G., Pallás M., Pubill D., Verdaguer E.Fuentes:scopusCalpains as a target for therapy of neurodegenerative diseases: Putative role of lithium
ReviewAbstract: Lithium is a simple cation that has been used clinically since 1950 for the treatment of bipolar disPalabras claves:apoptosis, Calcium homeostasis, Calpain, Cell cycle control, Cytoskeleton, DNA damage, Kinases, Lithium, Neurodegeneration, neurodegenerative diseases, signal transduction, Tau kinasesAutores:Antoni Camins, Canudas A.M., Crespo-Biel N., Junyent F., Pallás M., Verdaguer E.Fuentes:scopusATM is involved in cell-cycle control through the regulation of retinoblastoma protein phosphorylation
ArticleAbstract: Ataxia telangiectasia mutated protein (ATM) is a member of the phosphatidylinositol-3 kinase (PI3K)Palabras claves:apoptosis, ATM, cell cycle, KU-55933, Retinoblastoma protein, siRNAAutores:Antoni Camins, de la Torre A.V., Folch J., Jordan J., Junyent F., Pallás M., Pizarro J.G., Verdaguer E.Fuentes:scopusActivation of ataxia telangiectasia muted under experimental models and human Parkinson's disease
ArticleAbstract: In the present study we demonstrated that neurotoxin MPP +-induced DNA damage is followed by ataxiaPalabras claves:apoptosis, ATM, B65 neuroblastoma, cell cycle, MPP +, Parkinson's Disease, Retinoblastoma proteinAutores:Alvira D., Antoni Camins, de la Torre A.V., Ferrer I., Folch J., Gutiérrez-Cuesta J., Jordan J., Junyent F., Pallás M., Pizarro J.G., Sureda F.X., Verdaguer E.Fuentes:scopusGSK3β inhibition is involved in the neuroprotective effects of cyclin-dependent kinase inhibitors in neurons
ArticleAbstract: In the present study, we evaluated the effects of roscovitine (Rosco) and flavopiridol (Flavo), bothPalabras claves:apoptosis, Cerebellar granular cells, flavopiridol, GSK3β, RoscovitineAutores:Antoni Camins, Auladell C., de la Torre A.V., Folch J., Junyent F., Pallás M., Pelegrí Gabalda C., Verdaguer E., Vilaplana J., Zárate C.B.Fuentes:scopusEffects of MPP<sup>+</sup> on the molecular pathways involved in cell cycle control in B65 neuroblastoma cells
ArticleAbstract: The toxicity caused by cell exposure to 1-methyl-4-phenylpyridinium ion (MPP+) is a useful model inPalabras claves:apoptosis, Caspases, cell cycle, γH2AXAutores:Antoni Camins, Folch J., Jordan J., Junyent F., Pallás M., Pizarro J.G., Verdaguer E., Zárate C.B.Fuentes:scopusNeurotoxicity of amphetamine derivatives is mediated by caspase pathway activation in rat cerebellar granule cells
ArticleAbstract: The neurotoxic action of the abuse drugs methamphetamine (METH) and 3,4-methylenedioxymethamphetaminPalabras claves:apoptosis, Caspases, Cerebellar granule neurones, Cytochrome c, MDMA, MethamphetamineAutores:Antoni Camins, Camarasa J., Canudas A.M., Escubedo E., Jiménez A., Jordá E.G., Pallás M., Pubill D., Sureda F.X., Verdaguer E.Fuentes:scopusOxidative stress-induced DNA damage and cell cycle regulation in B65 dopaminergic cell line
ArticleAbstract: Reactive oxygen species and oxidative stress are associated with neuronal cell death in many neurodePalabras claves:apoptosis, ATM, cell cycle, KU-55933, Retinoblastoma proteinAutores:Antoni Camins, Folch J., Jordan J., Junyent F., Pallás M., Pizarro J.G., Vázquez De La Torre A., Verdaguer E.Fuentes:scopus