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A novel rhein-huprine hybrid ameliorates disease-modifying properties in preclinical mice model of Alzheimer’s disease exacerbated with high fat diet
ArticleAbstract: Background: Alzheimer’s disease (AD) is characterized by a polyetiological origin. Despite the globaPalabras claves:Alzheimer’s disease, BACE1, BDNF, cognitive decline, dendritic spines, high-fat diet, neuroinflammation, Rhein-huprine hybrid, Tau, TLR4Autores:Antoni Camins, Auladell C., Bulló M., Cano A., Espinosa-Jimenez T., Ettcheto M., Folch J., Muñoz-Torrero D., Olloquequi J., Parcerisas A., Pont C., Sanchez-Lopez E., Verdaguer E.Fuentes:scopusJNK1 and JNK3: divergent functions in hippocampal metabolic-cognitive function
ArticleAbstract: Background and aim: The appearance of alterations in normal metabolic activity has been increasinglyPalabras claves:COGNITION, high-fat diet, JNK1, JNK3, metabolismAutores:Antoni Camins, Auladell C., Bulló M., Busquets O., Cantero J.L., Carro E., Casadesús G., Espinosa-Jimenez T., Ettcheto M., Folch J., Olloquequi J., Verdaguer E.Fuentes:scopusc-Jun N-terminal Kinase 1 ablation protects against metabolic-induced hippocampal cognitive impairments
ArticleAbstract: Abstract: The development of metabolic alterations like insulin resistance has been associated withPalabras claves:c-Jun N-terminal Kinase 1, Cognitive impairments, high-fat dietAutores:Antoni Camins, Auladell C., Bulló M., Busquets O., Casadesús G., Castro-Torres R.D., Eritja À., Espinosa-Jimenez T., Ettcheto M., Folch J., Olloquequi J., Verdaguer E., Zárate C.B.Fuentes:scopus