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Article(6)
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Journal of Biological Chemistry(3)
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scopus(6)
Activation of HIF-prolyl hydroxylases by R59949, an inhibitor of the diacylglycerol kinase
ArticleAbstract: Hypoxia-inducible factors (HIF) are heterodimeric (α/β) transcription factors that play a fundamentaPalabras claves:Autores:Acosta-Iborra B., Aragonés J., Castellanos M.C., Feijóo-Cuaresma M., Manuel Ortiz de Landázuri, Martin-Puig S., Olmos G., Temes E.Fuentes:scopusGeneration of a highly sensitive reporter plasmid for the detection of the transcripcional response to hypoxia
ArticleAbstract: Decreased oxygen supply to the tissues at both systemic and local level induces a genic program whicPalabras claves:HIF-1α, Hypoxia, transcription factorsAutores:Alfranca A., Aragonés J., Manuel Ortiz de Landázuri, Temes E., Vara A.Fuentes:scopusVon Hippel-Lindau tumor suppressor protein regulates the assembly of intercellular junctions in renal cancer cells through hypoxia-inducible factor-independent mechanisms
ArticleAbstract: Inactivation of the von Hippel-Lindau (VHL) tumor suppressor gene is responsible for the developmentPalabras claves:Autores:Calzada M.J., Castellanos M.C., Esteban M.A., Feijóo-Cuaresma M., Manuel Ortiz de Landázuri, Méndez F., Naranjo-Suárez S., Ohh M., Temes E., Yáñez-Mó M.Fuentes:scopusRole of Iron (II)-2-Oxoglutarate-dependent Dioxygenases in the Generation of Hypoxia-induced Phosphatidic Acid through HIF-1/2 and von Hippel-Lindau-independent Mechanisms
ArticleAbstract: Hypoxia-inducible factors (HIF-1/HIF-2) govern the expression of critical genes for cellular adaptatPalabras claves:Autores:Aragonés J., Jones D.R., Manuel Ortiz de Landázuri, Martin-Puig S., Olmos G., Temes E.Fuentes:scopusRole of diacylglycerol induced by hypoxia in the regulation of HIF-1α activity
ArticleAbstract: Hypoxia-inducible factor 1 (HIF-1) is a critical transcription factor for the adaptation to loweredPalabras claves:Diacylglycerol, HIF-1, Hypoxia, Lipid second messengers, Phosphatidic acid, Protein regulation, signal transductionAutores:Aragonés J., Jones D.R., Manuel Ortiz de Landázuri, Martin-Puig S., Mérida I., Olmos G., Temes E.Fuentes:scopusThe von Hippel Lindau/hypoxia-inducible factor (HIF) pathway regulates the transcription of the HIF-proline hydroxylase genes in response to low oxygen
ArticleAbstract: Most of the genes induced by hypoxia are regulated by a family of transcription factors termed hypoxPalabras claves:Autores:Castellanos M.C., Cuevas Y., Manuel Ortiz de Landázuri, Martin-Puig S., Olmos G., Peso L.D., Temes E.Fuentes:scopus