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Article(9)
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Journal of Medicinal Chemistry(3)
Amino Acids(1)
Biochimica et Biophysica Acta - Molecular Cell Research(1)
Bioorganic and Medicinal Chemistry Letters(1)
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Microorganismos, hongos y algas(4)
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scopus(9)
A BODIPY-embedding miltefosine analog linked to cell-penetrating Tat(48-60) peptide favors intracellular delivery and visualization of the antiparasitic drug
ArticleAbstract: Therapeutic application of many drugs is often hampered by poor or denied access to intracellular taPalabras claves:BODIPY, cell-penetrating peptide, Dual fluorescent labeling, Miltefosine, Monitoring of intracellular drug delivery, Reversion of resistanceAutores:Abengózar M.Á., Amat-Guerri F., Andreu D., B. G. De la Torre, Hornillos V., Luque-Ortega J.R., Rivas L., Ulises Acuña A.Fuentes:scopusDefeating Leishmania resistance to Miltefosine (hexadecylphosphocholine) by peptide-mediated drug smuggling: A proof of mechanism for trypanosomatid chemotherapy
ArticleAbstract: Miltefosine (hexadecylphosphocholine, HePC), the first orally active drug successful against leishmaPalabras claves:cell-penetrating peptide, LEISHMANIA, Miltefosine, Resistance reversion, Tat, TrypanosomaAutores:Acuña A.U., Amat-Guerri F., Andreu D., B. G. De la Torre, Bart J.M., Hornillos V., Luque-Ortega J.R., Navarro M., Rivas L., Rueda C.Fuentes:scopusLysine N <sup>ε</sup>-trimethylation, a tool for improving the selectivity of antimicrobial peptides
ArticleAbstract: The effects of lysine N?-trimethylation at selected positions of the antimicrobial cecropin A?melittPalabras claves:Autores:Andreu D., B. G. De la Torre, Cabrales-Rico A., Díaz D., Fernández-Reyes M., Jiménez-Barbero J., Rivas L., Vallès-Miret M.Fuentes:scopusSequence inversion and phenylalanine surrogates at the β-Turn enhance the antibiotic activity of gramicidin S
ArticleAbstract: A series of gramicidin S (GS) analogues have been synthesized where the Phe (i + 1) and Pro (i + 2)Palabras claves:Autores:Andreu D., B. G. De la Torre, Cativiela C., Fernández-Reyes M., Jiménez A.I., Jiménez M.A., Rivas L., Santiveri C.M., Solanas C.Fuentes:scopusStructural framework for the modulation of the activity of the hybrid antibiotic peptide cecropin A-melittin [CA(1-7)M(2-9)] by N <sup>ε</sup>-lysine trimethylation
ArticleAbstract: The 3D structures of six linear pentadecapeptides derived from the cecropin A-melittin antimicrobialPalabras claves:Antimicrobial peptides (AMPs), cecropin A, membranes, NMR spectroscopy, TrimethyllysineAutores:Andreu D., B. G. De la Torre, Díaz M.D., Fernández-Reyes M., Jiménez-Barbero J., Rivas L.Fuentes:scopusStudies on the antimicrobial activity of cecropin A-melittin hybrid peptides in colistin-resistant clinical isolates of Acinetobacter baumannii
ArticleAbstract: Objectives: Acinetobacter baumannii has successfully developed resistance against all common antibioPalabras claves:A. baumannii, bactericidal activity, Capsule, colistin resistance, PolymyxinAutores:Andreu D., B. G. De la Torre, Docobo-Pérez F., Fernández-Cuenca F., García-Curiel A., Pachón J., Pachón-Ibañez M.E., Rivas L., Rodríguez-Hernández M.J., Saugar J.M.Fuentes:scopusSynthesis of 16-mercaptohexadecylphosphocholine, a miltefosine analog with leishmanicidal activity
ArticleAbstract: The alkylphosphocholine miltefosine (n-hexadecylphosphocholine, MT) has been introduced recently asPalabras claves:Hexadecylphosphocholine, LEISHMANIA, Mercaptophosphocholine, Miltefosine, ParasiticideAutores:Acuña A.U., Amat-Guerri F., Andreu D., B. G. De la Torre, Hornillos V., Rivas L., Saugar J.M.Fuentes:scopusThe induction of NOS2 expression by the hybrid cecropin A-melittin antibiotic peptide CA(1-8)M(1-18) in the monocytic line RAW 264.7 is triggered by a temporary and reversible plasma membrane permeation
ArticleAbstract: There is an increasing awareness of immune cell modulation by antimicrobial peptides. While this proPalabras claves:Antimicrobial peptide, Cecropin A-melittin, electrophysiology, macrophageAutores:Andreu D., Arias C., B. G. De la Torre, Guerrero E., Guizy M., Luque-Ortega J.R., Rivas L., Valenzuela C.Fuentes:scopusTherapeutic index of gramicidin S is strongly modulated by D-phenylalanine analogues at the β-turn
ArticleAbstract: Analogues of the cationic antimicrobial peptide gramicidin S (GS), cyclo(Val-Orn-Leu-D-Phe-Pro)2, wiPalabras claves:Autores:Andreu D., B. G. De la Torre, Cativiela C., Fernández-Reyes M., Jiménez A.I., Jiménez M.A., Rivas L., Santiveri C.M., Solanas C.Fuentes:scopus