Mostrando 10 resultados de: 34
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OMICS A Journal of Integrative Biology(6)
Drug Metabolism and Drug Interactions(4)
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Farmacología y terapéutica(25)
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A one-year follow-up study of treatment-compliant suicide attempt survivors: relationship of CYP2D6-CYP2C19 and polypharmacy with suicide reattempts
ArticleAbstract: This study of a cohort of 1-year treatment-compliant survivors of a suicide attempt examined for thePalabras claves:Autores:Adrián LLerena, Cortés-Martínez A., Courtet P., de Andrés F., Dubois J., Emilie Olié, Guillaume S., Kahn J.P., Leboyer M., Olié E., Penãs-Lledó E.M.Fuentes:scopusA rapid and simple LC-MS/MS method for the simultaneous evaluation of CYP1A2, CYP2C9, CYP2C19, CYP2D6 and CYP3A4 hydroxylation capacity
ArticleAbstract: Background: The analytical method here reported for the CEIBA cocktail approach has been developed aPalabras claves:Autores:Adrián LLerena, de Andrés F., Sosa-Macías M.G.Fuentes:scopusThe psychostimulant khat (Catha edulis) inhibits CYP2D6 enzyme activity in humans
ArticleAbstract: The use of khat (Catha edulis) while on medication may alter treatment outcome. In particular, the iPalabras claves:cathine, cathinone, CYP2D6, dextromethorphan, drug interaction, khatAutores:Adrián LLerena, Aklillu E., Beck O., Bedada W., Bertilsson L., de Andrés F., Engidawork E., Pohanka A., Worku BedadaFuentes:scopusTo Genotype or Phenotype for Personalized Medicine? CYP450 Drug Metabolizing Enzyme Genotype-Phenotype Concordance and Discordance in the Ecuadorian Population
ArticleAbstract: Genetic variations within the cytochrome P450 (CYP450) superfamily of drug metabolizing enzymes confPalabras claves:Biomarkers, developing world omics, Diagnostic Medicine, Innovation Systems, personalized medicine, Systems DiagnosticsAutores:Adrián LLerena, de Andrés F., Enrique Terán, Francisco J.López Hernández, Santiago TeránFuentes:googlescopusWater pipe (Shisha, Hookah, Arghile) Smoking and Secondhand Tobacco Smoke Effects on CYP1A2 and CYP2A6 Phenotypes as Measured by Caffeine Urine Test
ArticleAbstract: Public policies to stop or reduce cigarette smoking and exposure to secondhand smoke and associatedPalabras claves:Biomarkers, developing world omics, Diagnostic Medicine, drug development and OMICS, personalized medicineAutores:Adrián LLerena, de Andrés F., Erciyas K., Gündoǧar H., Güngör K., Karakaş Ü., Kimyon S., Mete A., Özdemir V., Yllmaz S.G.Fuentes:scopusWorldwide interethnic variability and geographical distribution of CYP2C9 genotypes and phenotypes
ReviewAbstract: Introduction: Notably differences in CYP2C9 allele frequencies among worldwide populations have beenPalabras claves:CYP2C9, ethnicity, Genotype, PhenotypeAutores:Adrián LLerena, Céspedes-Garro C., de Andrés F., Fricke-Galindo I., Humberto Fariñas, López-López M., Naranjo M.E.G., Penãs-Lledó E.M., Rodrigues-Soares F.Fuentes:scopusVEGF-related polymorphisms identified by GWAS and risk for major depression
ArticleAbstract: Depression is a common, severe, disabling mental disease that affects millions of people of all agesPalabras claves:Autores:Adrián LLerena, Cobaleda J., de Andrés F., Delgado A., G. Siest, Lamont J., Martin M., Murray H., Penãs-Lledó E.M., Siest G., Stathopoulou M.G., Visvikis-Siest S., Xie T.Fuentes:scopusCurrent insights into interethnic variability in testicular cancers: Population pharmacogenetics, clinical trials, genetic basis of chemotherapyinduced toxicities and molecular signal transduction
ReviewAbstract: Testicular cancer is an aggressive malignancy with a rising incidence rate across the globe. TesticuPalabras claves:clinical trials, ethnicity, Molecular aspects, pharmacogenetics, Pharmacogenomics, population pharmacogenetics, Precision Medicine, signal transduction, Testicular cancer, Testicular seminoma, toxicity, Variant polymorphismAutores:Adrián LLerena, de Andrés F., Kothari R., Mishra A., Nair S., Vasistha A.Fuentes:scopusCurrent perspectives on interethnic variability in multiple myeloma: Single cell technology, population pharmacogenetics and molecular signal transduction
ArticleAbstract: Multiple myeloma (MM) is an aggressive cancer characterised by malignancy of the plasma cells and aPalabras claves:Cancer, Drug resistance, Interethnic variability, Molecular aspects, Multiple myeloma, population pharmacogenetics, Precision Medicine, signal transductionAutores:Adrián LLerena, Bakhai V., de Andrés F., Gandhi M., Mishra A., Nair S., Rohit Sharma, Sharma R., Trivedi J.Fuentes:scopusCYP450 Genotype/Phenotype Concordance in Mexican Amerindian Indigenous Populations-Where to from Here for Global Precision Medicine?
ArticleAbstract: Global precision medicine demands characterization of drug metabolism and phenotype variation in divPalabras claves:Biomarkers, developing world omics, drug metabolism variation, global personalized medicine, Systems DiagnosticsAutores:Adrián LLerena, de Andrés F., Naranjo M.E.G., Ramos B., Sosa-Macías M.G.Fuentes:scopus