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Colchicine and aspirin in community patients with COVID-19 (ACT): an open-label, factorial, randomised, controlled trial
ArticleAbstract: Background: The large number of patients worldwide infected with the SARS-CoV-2 virus has overwhelmePalabras claves:Autores:Ali Z., Anand S.S., Avezum A.J., Bangdiwala S.I., Belley-Cote E.P., Berwanger O., Bosch J.J., Choudhri S., Dans A.L., Eikelboom J.W., Farkouh M.E., Felix Camilo, Harper W.L., Hassany M., Heenan L., Jolly S.S., Kontsevaya A., Loeb M., Lopes R.D., Pais P., Palileo-Villanueva L.M., PATRICIO LOPEZ -JARAMILLO, Rangarajan S., Sharma S.K., Tarhuni W.M., Wasserman S., Whitlock R.P., Xavier D., Xu L., Yusuf S., Yusufali A.M.Fuentes:googlescopusDesign and baseline characteristics of participants in the Researching cardiovascular Events with a Weekly INcretin in Diabetes (REWIND) trial on the cardiovascular effects of dulaglutide
ArticleAbstract: The aim was to determine the effects of dulaglutide, a synthetic once-weekly, injectable human glucaPalabras claves:antidiabetic drug, Cardiovascular disease, Clinical trial, diabetes complications, GLP-1 receptor agonistAutores:Atisso C.M., Avezum A.J., Basile J.N., Cardona-Munoz E.G., Chung N., Colhoun H.M., Conget I., Cushman W.C., Dagenais G.R., DIaz R., Franek E., Gerstein H.C., Hâncu N., Hanefeld M., Holt S., Jansky P., Keltai M., Lakshmanan M., Lanas F., Leiter L.A., Pais P., PATRICIO LOPEZ -JARAMILLO, Pirags V., Pogosova N., Probstfield J.L., Raubenheimer P.J., Riddle M.C., Rydén L.E., Shaw J.E., Sheu W.H.H., Temelkova-Kurktschiev T., Xavier D.Fuentes:scopusFixed-dose combination therapies with and without aspirin for primary prevention of cardiovascular disease: an individual participant data meta-analysis
ArticleAbstract: Background: In randomised controlled trials, fixed-dose combination treatments (or polypills) have bPalabras claves:Autores:Avezum A.J., Bangdiwala S.I., Bosch J.J., Castellano J.M., Dagenais G.R., Dans A.M., DIaz R., Fuster V., Gamra H., Gao P., Huffman M.D., Joseph P.G., Liu L., Lonn E.M., Malekzadeh R., Pais P., PATRICIO LOPEZ -JARAMILLO, Prabhakaran D., Rodgers A., Roshandel G., Sliwa K., Teo K.K., Xavier D., Yusuf S., Zhu J.Fuentes:googlescopusErectile function in men with type 2 diabetes treated with dulaglutide: an exploratory analysis of the REWIND placebo-controlled randomised trial
ArticleAbstract: Background: Diabetes is a major risk factor for erectile dysfunction, however, the effect of GLP-1 rPalabras claves:Autores:Bajaj H.S., Basile J.N., Colhoun H.M., Conget I., Cushman W.C., Dagenais G.R., Franek E., Gerstein H.C., Hanefeld M., Keltai M., Lakshmanan M., Lanas F.T., Leiter L.A., PATRICIO LOPEZ -JARAMILLO, Pirags V., Pogosova N., Probstfield J.L., Rao-Melacini P., Raubenheimer P.J., Rydén L.E., Shaw J.E., Sheu W.H.H., Xavier D.Fuentes:googlescopusEffect of a Perioperative Hypotension-Avoidance Strategy Versus a Hypertension-Avoidance Strategy on the Risk of Acute Kidney Injury: A Clinical Research Protocol for a Substudy of the POISE-3 Randomized Clinical Trial
ArticleAbstract: Background: Most patients who take antihypertensive medications continue taking them on the morningPalabras claves:acute kidney injury, antihypertensive medication, Hypotension, mean arterial pressure, noncardiac surgeryAutores:Aguado H.J., Amir M., Belley-Cote E.P., Bhatt K., Biccard B.M., Borges F.K., Chan M.T.V., Conen D., Cuerden M., Devereaux P.J., Duceppe E., Efremov S., Eikelboom J.W., Fleischmann E., Garg A.X., Giovanni L., Gross P.L., Jayaram R., Kirov M., Kleinlugtenbelt Y.V., Kurz A., Lamy A., Leslie K., Likhvantsev V.V., Lomivorotov V.V., Ma José Martínez Zapata, Marcucci M., McGillion M.H., McIntyre W., Meyhoff C.S., Ofori S.N., Painter T.W., Paniagua P., Parikh C., Parlow J.L., Patel A., Polanczyk C.A., Richards T., Roshanov P.S., Schmartz D., Sessler D.I., Short T.G., Sontrop J.M., Spence J., Srinathan S., Stillo D., Szczeklik W., Tandon V., Torres D., Van Helder T., Vincent J., Wang C.Y., Wang M.K., Whitlock R.P., Wittmann M., Xavier D.Fuentes:scopusDulaglutide and renal outcomes in type 2 diabetes: an exploratory analysis of the REWIND randomised, placebo-controlled trial
ArticleAbstract: Background: Two glucagon-like peptide-1 (GLP-1) receptor agonists reduced renal outcomes in people wPalabras claves:Autores:Abella M., Alebuena A., Almagro S., Amoroso E., Anadon P., Andreu E., Aristimuño G., Arzadun M., Atisso C.M., Avezum A.J., Barbieri M., Barcudi R., BARTOLACCI I.P., Basile J.N., Bolobanich G., BORDONAVA A.P., Botros F.T., Bustamante Labarta M., Bustos B., CACCAVO A., Camino A., Cantero M., Cardona-Munoz E.G., Carignano M., CARTASEGNA L.U.I.S., Chung N., Cipullo M., Colhoun H.M., Commendatore V., Conget I., Conosciuto V., Costamagna O., Crespo C., Cuello J.L., Cuneo C.A., Cushman W.C., Cusimano S., Dagenais G.R., Dean S., DIaz R., Dituro C., Dominguez A., Dyal L., Farah M., Fernandez A., Fernandez F., Ferrari A., Flammia P., Franek E., Fuentealba J., Gallardo K.B., Garcia C., GARCIA DURAN R.O., GARRIDO M., Gavicola R., Gerbaudo C., Gerstein H.C., Gilli G., Giotto A.P., Godoy Bolzán P., Gomez Vilamajo O., Guerlloy F., Guridi C., Gutierrez Garrido N., Hall S., Hâncu N., Hanefeld M., HASBANI E., Hermida S., Holt S., HOMINAL M.A., HRABAR A., Ingaramo A., Izzicupo A., Jansky P., Keltai M., Krynski M., Lagrutta M., Lakshmanan M., Lanas F.T., Lanchiotti P., Langhe M., Leiter L.A., Leonard V., Llanos J., López-Santi R., Pais P., PATRICIO LOPEZ -JARAMILLO, Pirags V., Pogosova N., Probstfield J.L., Rao-Melacini P., Raubenheimer P.J., Riddle M.C., Rydén L.E., Shaw J.E., Sheu W.H.H., Temelkova-Kurktschiev T., Washington Stalin García Cuenta, Wong G., Xavier D.Fuentes:googlescopusEffects of a Polypill, Aspirin, and the Combination of Both on Cognitive and Functional Outcomes: A Randomized Clinical Trial
ArticleAbstract: Importance: Vascular risk factors are associated with cognitive decline but studies addressing indivPalabras claves:Autores:Bosch J.J., Dans A.M., Gao P., Joseph P.G., O'donnell M.J., Pais P., PATRICIO LOPEZ -JARAMILLO, Xavier D., Yusuf S.Fuentes:scopusEffects of extended-release metoprolol succinate in patients undergoing non-cardiac surgery (POISE trial): A randomised controlled trial
ArticleAbstract: Background: Trials of β blockers in patients undergoing non-cardiac surgery have reported conflictinPalabras claves:Autores:Aggarwala R., Alonso-Coello P., Argibay-Poliquin E., Avezum A.J., Badner N., Baer C., Baidel Y., Baptista M., Barratt S., Beattie W.S., Bednarowski M., Beilby D., Bertozzi H.A., Berwanger O., Blacher C., Bodanese L.C., Boisvenu G., Bolsin S., Boulton A., Boyd D., Brunet D., Bryson G.L., Bugler S., Burlingham J., Caccavo R.A., Campeau J., Campos De Albuquerque D., Carlos Zevallos J., Chan M.T.V., Choi P., Chrolavicius S., Ciapponi A., Cope L., Devereaux P.J., Do Amara Baruzzi A.C., Douglas J., Esteves J.P., Faller J., Fatovich S., Ferrari A., Foëx P., França Neto O.R., Gannedahl P., Garcia Dieguez M., Giles J., Goldman L., Grant J., Greenspan L., Guiselli Gallina L.E., Guyatt G.H., Halliwell R., Hudson R.J., Islas Andrade S., Izukawa N.M., Jacka M.J., Kallas F.C., Keltai M., Kerr Saraiva J.F., Kerridge R.K., Leino K., Leslie K., Liu L., Love J., Málaga G., March S., Marin-Neto J.A., Mauricio Espinel, McCulloch T.J., Montori V.M., Myles P.S., Nicolosi L.N., Nigro Maia L., Paech M., Pais P., Penha Rosateli P.H., Peyton P., Phrommintikul A., Pogue J., Poole C., Poustie S., Priestly M., Rabello R., Raeder J., Reeves M., Salazar A., Schammass Ducatti T., Schricker T., Sear J., Sierra F., Tesolin P., Tristan M., Urŕutia G., Wallace S., Warriner B., Weitkamp B., Wolfers D., Xavier D., Xu S., Yang H., Yusuf S.Fuentes:scopusNovel Approaches in Primary Cardiovascular Disease Prevention: The HOPE-3 Trial Rationale, Design, and Participants' Baseline Characteristics
ArticleAbstract: Background: Cholesterol and blood pressure (BP) can be effectively and safely lowered with statin drPalabras claves:Autores:Avezum A.J., Bosch J.J., Chazova I.E., Dagenais G.R., Dans A.M., DIaz R., Fodor G.J., Held C., Jansky P., Keltai K., Keltai M., Kim J.H., Kunti K., Leiter L.A., Lewis B.S., Liu L., Lonn E.M., Pais P., Parkhomenko A.N., PATRICIO LOPEZ -JARAMILLO, Peters R.J.G., Piegas L.S., Pogue J., Reid C.M., Sliwa K., Toff W.D., Varigos J.D., Xavier D., Yusoff K., Yusuf S., Zhu J.Fuentes:googlescopusLowering cholesterol, blood pressure, or both to prevent cardiovascular events: Results of 8.7 years of follow-up of Heart Outcomes Evaluation Prevention (HOPE)-3 study participants
ArticleAbstract: Aims: Rosuvastatin (10 mg per day) compared with placebo reduced major adverse cardiovascular (CV) ePalabras claves:Cardiovascular disease, Primary Prevention, statinsAutores:Avezum A.J., Bosch J.J., Dagenais G.R., Dans A.M., DIaz R., Held C., Jansky P., Joseph P.G., Jung H., Keltai K., Keltai M., Khunti K., Leiter L.A., Lewis B.S., Liu L., Lonn E.M., Pais P., Parkhomenko A.N., PATRICIO LOPEZ -JARAMILLO, Peters R.J.G., Piegas L.S., Reid C.M., Sliwa K., Toff W.D., Varigos J.D., Xavier D., Yusoff K., Yusuf S., Zhu J.Fuentes:googlescopus