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Design and Synthesis of Broad Spectrum Trypanosomatid Selective Inhibitors
ArticleAbstract: Neglected tropical diseases caused by parasitic infections are an ongoing and increasing concern thaPalabras claves:chemical tools, drug design, Natural products, photoaffinity, TrypanosomatidAutores:Florence G.J., Fraser A.L., Gould E.R., King E.F.B., Smith T.K., Stefanie K. Menzies, Tulloch L.B., Zacharova M.K.Fuentes:scopusStructure-Based Design, Synthesis and Biological Evaluation of Bis-Tetrahydropyran Furan Acetogenin Mimics Targeting the Trypanosomatid F1 Component of ATP Synthase
ArticleAbstract: The protozoan parasites Trypanosoma brucei, Trypanosoma cruzi and Leishmania spp. are responsible foPalabras claves:biological activity, drug design, FoF1-ATP synthase, homogeneous catalysis, TrypanosomatidAutores:Florence G.J., Fraser A.L., Gould E.R., King E.F.B., Smith T.K., Stefanie K. Menzies, Tulloch L.B., Zacharova M.K.Fuentes:scopus