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Development of Simplified Heterocyclic Acetogenin Analogues as Potent and Selective Trypanosoma brucei Inhibitors
ArticleAbstract: Neglected tropical diseases caused by parasitic infections are an ongoing and increasing concern. ThPalabras claves:Drug Discovery, natural product analogues, trypanosomatids, [3+2] cycloadditionAutores:Florence G.J., Fraser A.L., Gould E.R., King E.F.B., Morris J.C., Smith T.K., Stefanie K. Menzies, Thomson M.I., Tulloch L.B., Zacharova M.K.Fuentes:scopusDesign and Synthesis of Broad Spectrum Trypanosomatid Selective Inhibitors
ArticleAbstract: Neglected tropical diseases caused by parasitic infections are an ongoing and increasing concern thaPalabras claves:chemical tools, drug design, Natural products, photoaffinity, TrypanosomatidAutores:Florence G.J., Fraser A.L., Gould E.R., King E.F.B., Smith T.K., Stefanie K. Menzies, Tulloch L.B., Zacharova M.K.Fuentes:scopusDirect and indirect approaches to identify drug modes of action
ReviewAbstract: Phenotypic assays are becoming increasingly more common among drug discovery practices, expanding drPalabras claves:affinity chromatography, drug mode of action, Genomics, Metabolomics, photo-affinity labeling, proteomics, target ID, transcriptomicsAutores:Coron R.P., Florence G.J., Roberts M.D., Smith T.K., Stefanie K. Menzies, Tulloch L.B.Fuentes:scopusNon-natural Acetogenin Analogues as Potent Trypanosoma brucei Inhibitors
ArticleAbstract: Neglected tropical diseases remain a serious global health concern. Here, a series of novel bis-tetrPalabras claves:acetogenin, Human African Trypanosomiasis (HAT), natural product analogues, Neglected diseases, stereochemistry, Trypanosoma bruceiAutores:Florence G.J., Fraser A.L., Gould E.R., King E.F.B., Morris J.C., Smith T.K., Stefanie K. Menzies, Tulloch L.B.Fuentes:scopusPhoto-affinity labelling and biochemical analyses identify the target of trypanocidal simplified natural product analogues
ArticleAbstract: Current drugs to treat African sleeping sickness are inadequate and new therapies are urgently requiPalabras claves:Autores:Florence G.J., Fraser A.L., Gould E.R., King E.F.B., Smith T.K., Stefanie K. Menzies, Tulloch L.B., Zacharova M.K.Fuentes:scopusSimplifying nature: Towards the design of broad spectrum kinetoplastid inhibitors, inspired by acetogenins
ArticleAbstract: The need for new treatments for the neglected tropical diseases African sleeping sickness, Chagas diPalabras claves:Acetogenins, Natural products, neglected tropical diseases, TetrahydropyranAutores:Florence G.J., Fraser A.L., Gould E.R., King E.F.B., Smith T.K., Stefanie K. Menzies, Tulloch L.B., Zacharova M.K.Fuentes:scopusStructure-Based Design, Synthesis and Biological Evaluation of Bis-Tetrahydropyran Furan Acetogenin Mimics Targeting the Trypanosomatid F1 Component of ATP Synthase
ArticleAbstract: The protozoan parasites Trypanosoma brucei, Trypanosoma cruzi and Leishmania spp. are responsible foPalabras claves:biological activity, drug design, FoF1-ATP synthase, homogeneous catalysis, TrypanosomatidAutores:Florence G.J., Fraser A.L., Gould E.R., King E.F.B., Smith T.K., Stefanie K. Menzies, Tulloch L.B., Zacharova M.K.Fuentes:scopusThe trypanosome alternative oxidase: A potential drug target?
ReviewAbstract: New drugs against Trypanosoma brucei, the causative agent of Human African Trypanosomiasis, are urgePalabras claves:chemotherapy, Drug Discovery, human African trypanosomiasis, Sleeping sickness, Trypanosoma brucei, Trypanosome alternative oxidaseAutores:Florence G.J., Smith T.K., Stefanie K. Menzies, Tulloch L.B.Fuentes:scopus