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British Journal of Pharmacology(1)
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Biodistribution and pharmacokinetics of PEG-10kDa-cholecystokinin-10 in rats after different routes of administration
ArticleAbstract: Cholecystokinin, produced in the proximal small intestine, is a short acting satiating peptide hormoPalabras claves:biodistribution, CCK-10, Peg10kda-cck-10, pharmacokinetics, SatietyAutores:Buyse J., Cokelaere M., De Cuyper M., De Witte P.A.M., Fabián León-Tamariz, van Boven M., Verbaeys I., Verbruggen A.Fuentes:scopusPEGylated cholecystokinin prolongs satiation in rats: Dose dependency and receptor involvement
ArticleAbstract: Background and purpose: Acute intraperitoneal (i.p.) administration of cholecystokinin (CCK) is knowPalabras claves:Anorexia, CCK receptor antagonists 1, Cholecystokinin, Devazepide 2-NAP, dose-response, PEGylated CholecystokininAutores:Buyse J., Cokelaere M., De Cuyper M., Fabián León-Tamariz, Pottel H., van Boven M., Verbaeys I.Fuentes:scopusPEGylation of cholecystokinin prolongs its anorectic effect in rats
ArticleAbstract: The anorectic compound CCK-9 was coupled to polyethylene glycol 5 kDa, 10 kDa, 20 kDa and 30 kDa, unPalabras claves:Appetite suppression, Cholecystokinin, Food intake, PegylationAutores:Buyse J., Clynen E., Cokelaere M., De Cuyper M., Fabián León-Tamariz, van Boven M., Verbaeys I.Fuentes:scopusSynthesis, characterization and satiety in rats of PEG10kDa-CCK-10 and (Radio)iodinated PEG10kDa-CCK-10
ArticleAbstract: The iodination of CCK-10 and coupling with PEG 10kDa is described along with evaluation of their fooPalabras claves:CCK-10, Cholecystokinin, Food intake, Peg10kda-cck-10, Pegylation, Satiety, [ ]-labeled cck-10 123, [ ]-labeled peg10kda- cck-10 123Autores:Buyse J., Clynen E., Cokelaere M., De Cuyper M., Fabián León-Tamariz, Lescrinier E., van Boven M., Verbaeys I., Verbruggen A.Fuentes:scopus