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Changes in oxidative stress parameters and neurodegeneration markers in the brain of the senescence-accelerated mice SAMP-8
ArticleAbstract: The senescence-accelerated strains of mice (SAMP) are well-characterized animal models of senescencePalabras claves:Calpain, Catalase, Neurodegeneration, Oxidative Stress, Senescence, TauAutores:Antoni Camins, Canudas A.M., Gutiérrez-Cuesta J., Mallol J., Mulero M., Pallás M., Romeu M., Sureda F.X.Fuentes:scopusChronic administration of melatonin reduces cerebral injury biomarkers in SAMP8
ArticleAbstract: Certain effects of melatonin on senescence were investigated. The experimental model used was 10-monPalabras claves:aging, ck5/p35, GSK3β, Oxidative Stress, SAMP8, TauAutores:Antoni Camins, Caballero B., Canudas A.M., Coto-Montes A., Gutiérrez-Cuesta J., Pallás M., Romeu M., Sureda F.X.Fuentes:scopusActivation of ataxia telangiectasia muted under experimental models and human Parkinson's disease
ArticleAbstract: In the present study we demonstrated that neurotoxin MPP +-induced DNA damage is followed by ataxiaPalabras claves:apoptosis, ATM, B65 neuroblastoma, cell cycle, MPP +, Parkinson's Disease, Retinoblastoma proteinAutores:Alvira D., Antoni Camins, de la Torre A.V., Ferrer I., Folch J., Gutiérrez-Cuesta J., Jordan J., Junyent F., Pallás M., Pizarro J.G., Sureda F.X., Verdaguer E.Fuentes:scopusActivation of the calpain/cdk5/p25 pathway in the girus cinguli in Parkinson's disease
ArticleAbstract: The mechanisms involved in neuronal loss in Parkinson's disease (PD) are not known, although recentPalabras claves:CDK5, cell cycle, E2F-1, Parkinson's DiseaseAutores:Alvira D., Antoni Camins, Ferrer I., Garcia-Castro B., Gutiérrez-Cuesta J., Pallás M.Fuentes:scopusFavorable effects of a prolonged treatment with melatonin on the level of oxidative damage and neurodegeneration in senescence-accelerated mice
ArticleAbstract: Senescence-accelerated mice (SAMP8) and senescence-accelerated resistant mice (SAMR1) were studied aPalabras claves:aging, BRAIN, Melatonin receptor-1, Neurofibrillary tangle, Nuclear factor-kappa B, Retinoic acid receptor-related orphan receptor-α1, Senescence-accelerated miceAutores:Antoni Camins, Caballero B., Coto-Montes A., Gonzalo-Calvo D.D., Gutiérrez-Cuesta J., Huidobro-Fernández C., Pallás M., Rodríguez-Colunga M.J., Sierra V., Soria-Valles C., Tolivia D., Vega-Naredo I.Fuentes:scopusDysfunction of astrocytes in senescence-accelerated mice SAMP8 reduces their neuroprotective capacity
ArticleAbstract: Early onset increases in oxidative stress and tau pathology are present in the brain of senescence-aPalabras claves:astrocytes, Glutamate uptake, neuroprotection, Oxidative Stress, Senescence-accelerated mice, Tau proteinAutores:Antoni Camins, Coto-Montes A., Cristòfol R., Díez-Vives C., García-Matas S., Gutiérrez-Cuesta J., Pallás M., Rubio-Acero R., Sanfeliu C.Fuentes:scopusNeuronal cell cycle re-entry markers are altered in the senescence accelerated mouse P8 (SAMP8)
ArticleAbstract: Senescence-accelerated mice 8 (SAMP8), a model of aging, display many established pathological featuPalabras claves:aging, Alzheimer's disease, CDK5, cell cycle, GSK3β, TauAutores:Antoni Camins, Casadesús G., Gutiérrez-Cuesta J., Jiménez A., Lee H.g., Ortuo-Sahagún D., Pallás M., Smith M.A., Tajes M.Fuentes:scopusNeuroprotective role of intermittent fasting in senescence-accelerated mice P8 (SAMP8)
ArticleAbstract: Dietary interventions have been proposed as a way to increase lifespan and improve health. The senesPalabras claves:ADAM10, ageing, BDNF, Neurodegeneration, NFκB, Sirtuin 1Autores:Antoni Camins, Folch J., Gutiérrez-Cuesta J., Jiménez A., Junyent F., Lau A., Ortuo-Sahagún D., Pallás M., Tajes M., Verdaguer E.Fuentes:scopusModulation of SIRT1 expression in different neurodegenerative models and human pathologies
ArticleAbstract: We examined the expression of SIRT1 in several experimental paradigms of human pathologies. We usedPalabras claves:3-nitropropionic acid, BRAIN, cell cycle, kainate, MPP+, rotenoneAutores:Alvira D., Antoni Camins, Canudas A.M., Crespo-Biel N., Ferrer I., Folch J., Gutiérrez-Cuesta J., Pallás M., Pizarro J.G., Sureda F.X., Tajes M., Yeste-Velasco M.Fuentes:scopusLithium treatment decreases activities of tau kinases in a murine model of senescence
ArticleAbstract: Lithium modulates glycogen synthase kinase 3β (GSK-3β), a kinase involved in Alzheimer disease-relatPalabras claves:aging, BRAIN, Lithium, Neurodegeneration, Senescence-accelerated mouseAutores:Antoni Camins, Caballero B., Casadesús G., Ferrer I., Folch J., Gutiérrez-Cuesta J., Pallás M., Smith M.A., Tajes M.Fuentes:scopus