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Dysfunction of astrocytes in senescence-accelerated mice SAMP8 reduces their neuroprotective capacity
ArticleAbstract: Early onset increases in oxidative stress and tau pathology are present in the brain of senescence-aPalabras claves:astrocytes, Glutamate uptake, neuroprotection, Oxidative Stress, Senescence-accelerated mice, Tau proteinAutores:Antoni Camins, Coto-Montes A., Cristòfol R., Díez-Vives C., García-Matas S., Gutiérrez-Cuesta J., Pallás M., Rubio-Acero R., Sanfeliu C.Fuentes:scopusEffects of melatonin in the brain of the senescence-accelerated mice-prone 8 (SAMP8) model
ArticleAbstract: Summary. Senescence-accelerated mice (SAM) represent an aging model establish by selective inbreedinPalabras claves:CDK5, GSK3beta, melatonin, TauAutores:Antoni Camins, Gutiérrez-Cuesta J., Jiménez A., Pallás M., Tajes M.Fuentes:scopusNeuronal cell cycle re-entry markers are altered in the senescence accelerated mouse P8 (SAMP8)
ArticleAbstract: Senescence-accelerated mice 8 (SAMP8), a model of aging, display many established pathological featuPalabras claves:aging, Alzheimer's disease, CDK5, cell cycle, GSK3β, TauAutores:Antoni Camins, Casadesús G., Gutiérrez-Cuesta J., Jiménez A., Lee H.g., Ortuo-Sahagún D., Pallás M., Smith M.A., Tajes M.Fuentes:scopusNeuroprotective role of intermittent fasting in senescence-accelerated mice P8 (SAMP8)
ArticleAbstract: Dietary interventions have been proposed as a way to increase lifespan and improve health. The senesPalabras claves:ADAM10, ageing, BDNF, Neurodegeneration, NFκB, Sirtuin 1Autores:Antoni Camins, Folch J., Gutiérrez-Cuesta J., Jiménez A., Junyent F., Lau A., Ortuo-Sahagún D., Pallás M., Tajes M., Verdaguer E.Fuentes:scopusModulation of SIRT1 expression in different neurodegenerative models and human pathologies
ArticleAbstract: We examined the expression of SIRT1 in several experimental paradigms of human pathologies. We usedPalabras claves:3-nitropropionic acid, BRAIN, cell cycle, kainate, MPP+, rotenoneAutores:Alvira D., Antoni Camins, Canudas A.M., Crespo-Biel N., Ferrer I., Folch J., Gutiérrez-Cuesta J., Pallás M., Pizarro J.G., Sureda F.X., Tajes M., Yeste-Velasco M.Fuentes:scopusLithium treatment decreases activities of tau kinases in a murine model of senescence
ArticleAbstract: Lithium modulates glycogen synthase kinase 3β (GSK-3β), a kinase involved in Alzheimer disease-relatPalabras claves:aging, BRAIN, Lithium, Neurodegeneration, Senescence-accelerated mouseAutores:Antoni Camins, Caballero B., Casadesús G., Ferrer I., Folch J., Gutiérrez-Cuesta J., Pallás M., Smith M.A., Tajes M.Fuentes:scopus