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Journal of Pineal Research(4)
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Changes in oxidative stress parameters and neurodegeneration markers in the brain of the senescence-accelerated mice SAMP-8
ArticleAbstract: The senescence-accelerated strains of mice (SAMP) are well-characterized animal models of senescencePalabras claves:Calpain, Catalase, Neurodegeneration, Oxidative Stress, Senescence, TauAutores:Antoni Camins, Canudas A.M., Gutiérrez-Cuesta J., Mallol J., Mulero M., Pallás M., Romeu M., Sureda F.X.Fuentes:scopusChronic administration of melatonin reduces cerebral injury biomarkers in SAMP8
ArticleAbstract: Certain effects of melatonin on senescence were investigated. The experimental model used was 10-monPalabras claves:aging, ck5/p35, GSK3β, Oxidative Stress, SAMP8, TauAutores:Antoni Camins, Caballero B., Canudas A.M., Coto-Montes A., Gutiérrez-Cuesta J., Pallás M., Romeu M., Sureda F.X.Fuentes:scopusAnti-aging properties of melatonin in an in vitro murine senescence model: Involvement of the sirtuin 1 pathway
ArticleAbstract: Sirtuin 1 is a member of the sirtuin family of protein deacetylases, which have attracted considerabPalabras claves:ADAM10, aging, Neurodegeneration, NFκB, Oxidative Stress, P53Autores:Antoni Camins, Gutiérrez-Cuesta J., Ortuo-Sahagún D., Pallás M., Tajes M.Fuentes:scopusActivation of ataxia telangiectasia muted under experimental models and human Parkinson's disease
ArticleAbstract: In the present study we demonstrated that neurotoxin MPP +-induced DNA damage is followed by ataxiaPalabras claves:apoptosis, ATM, B65 neuroblastoma, cell cycle, MPP +, Parkinson's Disease, Retinoblastoma proteinAutores:Alvira D., Antoni Camins, de la Torre A.V., Ferrer I., Folch J., Gutiérrez-Cuesta J., Jordan J., Junyent F., Pallás M., Pizarro J.G., Sureda F.X., Verdaguer E.Fuentes:scopusActivation of the calpain/cdk5/p25 pathway in the girus cinguli in Parkinson's disease
ArticleAbstract: The mechanisms involved in neuronal loss in Parkinson's disease (PD) are not known, although recentPalabras claves:CDK5, cell cycle, E2F-1, Parkinson's DiseaseAutores:Alvira D., Antoni Camins, Ferrer I., Garcia-Castro B., Gutiérrez-Cuesta J., Pallás M.Fuentes:scopusFavorable effects of a prolonged treatment with melatonin on the level of oxidative damage and neurodegeneration in senescence-accelerated mice
ArticleAbstract: Senescence-accelerated mice (SAMP8) and senescence-accelerated resistant mice (SAMR1) were studied aPalabras claves:aging, BRAIN, Melatonin receptor-1, Neurofibrillary tangle, Nuclear factor-kappa B, Retinoic acid receptor-related orphan receptor-α1, Senescence-accelerated miceAutores:Antoni Camins, Caballero B., Coto-Montes A., Gonzalo-Calvo D.D., Gutiérrez-Cuesta J., Huidobro-Fernández C., Pallás M., Rodríguez-Colunga M.J., Sierra V., Soria-Valles C., Tolivia D., Vega-Naredo I.Fuentes:scopusEvaluation of potential pro-survival pathways regulated by melatonin in a murine senescence model
ArticleAbstract: We examined the effect of melatonin on pro-survival processes in three groups of mice. Untreated senPalabras claves:aging, Amyloid β, BRAIN, Cysteine proteases, Sirt1Autores:Antoni Camins, Coto-Montes A., Gutiérrez-Cuesta J., Jiménez A., Pallás M., Tajes M.Fuentes:scopusDysfunction of astrocytes in senescence-accelerated mice SAMP8 reduces their neuroprotective capacity
ArticleAbstract: Early onset increases in oxidative stress and tau pathology are present in the brain of senescence-aPalabras claves:astrocytes, Glutamate uptake, neuroprotection, Oxidative Stress, Senescence-accelerated mice, Tau proteinAutores:Antoni Camins, Coto-Montes A., Cristòfol R., Díez-Vives C., García-Matas S., Gutiérrez-Cuesta J., Pallás M., Rubio-Acero R., Sanfeliu C.Fuentes:scopusEffects of melatonin in the brain of the senescence-accelerated mice-prone 8 (SAMP8) model
ArticleAbstract: Summary. Senescence-accelerated mice (SAM) represent an aging model establish by selective inbreedinPalabras claves:CDK5, GSK3beta, melatonin, TauAutores:Antoni Camins, Gutiérrez-Cuesta J., Jiménez A., Pallás M., Tajes M.Fuentes:scopusNeuronal cell cycle re-entry markers are altered in the senescence accelerated mouse P8 (SAMP8)
ArticleAbstract: Senescence-accelerated mice 8 (SAMP8), a model of aging, display many established pathological featuPalabras claves:aging, Alzheimer's disease, CDK5, cell cycle, GSK3β, TauAutores:Antoni Camins, Casadesús G., Gutiérrez-Cuesta J., Jiménez A., Lee H.g., Ortuo-Sahagún D., Pallás M., Smith M.A., Tajes M.Fuentes:scopus