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scopus(11)
Cytotoxic activity of seco-entkaurenes from Croton caracasana on human cancer cell lines
ArticleAbstract: In the course of searching for bioactive compounds from Croton species from Venezuela, two seco-entkPalabras claves:Croton caracasana, Cytotoxic, euphorbiaceae, seco-entkaurenesAutores:Alírica Isabel Suárez, Arvelo F.A., Chavez K., Compagnone R.S., de Sanctis J.B., Mateu E., Mijares M.R., Muñoz A., Sojo F.J.Fuentes:scopusCytotoxic effects of fisturalin-3 and 11-Deoxyfisturalin-3 on Jurkat and U937 cell lines
ArticleAbstract: Background. Fisturalines are bromotyrosine compounds isolated from marine sponges. Previous studiesPalabras claves:11-deoxyfistularin-3, Aplysina fistularis, Bromotyrosine, Cáncer, Fistularin-3, Leukemia, quercetinAutores:Alírica Isabel Suárez, Avila R., Barroeta A., Chirinos P., Compagnone R.S., de Sanctis J.B., Martinez G.P., Mijares M.R., Ochoa M.Fuentes:scopusCaracasine acid, an ent-3,4-seco-kaurene, promotes apoptosis and cell differentiation through NFkB signal pathway inhibition in leukemia cells.
ArticleAbstract: Caracasine acid (CA) is an ent-3,4-seco-kaurene isolated from the plant Croton micans. Decreased canPalabras claves:Annexin-V, apoptosis, Cáncer, Caracasine acid, Croton, Kaurene compounds, Leukemia, NF-κBAutores:Alírica Isabel Suárez, Chavez K., Chirinos P., Compagnone R.S., de Sanctis J.B., Martinez G.P., Mijares M.R.Fuentes:scopusNew antiinflammatory cycloart-23-ene-3β-ol from Senefelderopsis chibiriquetensis
ArticleAbstract: 1D and 2D NMR spectroscopic techniques were used to obtain the complete characterization of cycloartPalabras claves:Anti-Inflammatory, Cycloart-23-en-3β-ol, NMR, Senefelderopsis chiribiquetensis, TriterpenesAutores:Alírica Isabel Suárez, Canelón D.J., Compagnone R.S., De Sanctisc J., Mijares M.R.Fuentes:scopusNovel 7-Chloro-(4-thioalkylquinoline) Derivatives: Synthesis and Antiproliferative Activity through Inducing Apoptosis and DNA/RNA Damage
ArticleAbstract: A series of 78 synthetic 7-chloro-(4-thioalkylquinoline) derivatives were investigated for cytotoxicPalabras claves:antiproliferative activity, cell cycle, DNA/RNA damage, Sulfanyl-Sulfinyl-Sulfonyl groups, synthesis of 4-thioalkylquinolineAutores:Bruno-Colmenarez J., Charris J.E., de Sanctis J.B., Deffieux D., Džubák P., Esteban Fernández-Moreira, Gurská S., Gutiérrez J.E., Hajdůch M., Hegira Ramírez, Mijares M.R., Pouységu L., Quideau S., Rodríguez M.A., Rojas L.B.Fuentes:scopusIn vitro evaluation and in vivo efficacy of nitroimidazole-sulfanyl ethyl derivatives against Leishmania (V.) braziliensis and Leishmania (L.) mexicana
ArticleAbstract: The aim of this study was to synthesize several small molecules of the type 5-nitroimidazole-sulfanyPalabras claves:LEISHMANIA, Metronidazole, Nitroimidazole, PCR, SulfanylAutores:Blanco Z., Charris J.E., Esteban Fernández-Moreira, Hegira Ramírez, Mijares M.R., Oviedo H.J., Rodríguez N.M.Fuentes:scopusPharmacological properties of thalidomide and its analogues
ArticleAbstract: Thalidomide and its immunomodulatory imide drugs (IMiDs) analogues CC-5013 (Revlimid™, Lenalidomide)Palabras claves:Actimid, Angiogenesis, cytokines, DIABÉTES, Imids, Lenalidomide, Multiple myeloma, Pomalidomide, Prostate cancer, Revlimid, ThalidomideAutores:Alírica Isabel Suárez, Compagnone R.S., de Sanctis J.B., Garmendia J., Mijares M.R., Moreno D., Salazar-Bookaman M.Fuentes:scopusSynthesis and antimalarial and anticancer evaluation of 7-chlorquinoline-4-thiazoleacetic derivatives containing aryl hydrazide moieties
ArticleAbstract: Twelve 7-chloroquinoline derivatives were designed and synthesized using the principle of molecularPalabras claves:Antimalarial, Antiproliferative, apoptosis, hydrazides, quinoline, thiazolAutores:Celis C., Charris J.E., de Sanctis J.B., Esteban Fernandez, Hegira Ramírez, Martinez G.P., Mayora S., Mijares M.R., Rodrigues J.R.Fuentes:scopusSynthesis and biological activity of 2-[2-(7-chloroquinolin-4-ylthio)-4-methylthiazol-5-yl]-N-phenylacetamide derivatives as antimalarial and cytotoxic agents
ArticleAbstract: A novel series of 2-[2-(7-chloroquinolin-4-ylthio)-4-methylthiazol-5-yl]-N-phenylacetamide derivativPalabras claves:ANTICANCER, Antimalarial, plasmodium, quinoline, thiazoleacetic acidAutores:Charris J.E., de Sanctis J.B., Hegira Ramírez, Mijares M.R., Rodrigues J.R.Fuentes:scopusSynthesis and in silico ADME/Tox profiling studies of heterocyclic hybrids based on chloroquine scaffolds with potential antimalarial activity
ArticleAbstract: A series of heterocyclic chloroquine hybrids containing either a β-phenethylamine fragment or a 2-amPalabras claves:2-Aminoindane, Chloroquine, Hemozoin, MALARIA, β-PhenethylamineAutores:Ángel J.E., Charris J.E., Esteban Fernández-Moreira, Hegira Ramírez, Mijares M.R., Rodrigues J.R.Fuentes:scopus