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One-pot multicomponent synthesis of methoxybenzo[h]quinoline-3-carbonitrile derivatives; anti-chagas, X-ray, and in silico ADME/tox profiling studies
ArticleAbstract: Several methoxybenzo[h]quinoline-3-carbonitrile analogs were designed and synthesized in a repositioPalabras claves:Cáncer, chagas, Methoxybenzo[h]quinoline, One-pot synthesisAutores:Ángel J.E., Capparelli M.V., Charris J.E., Charris K.E., Esteban Fernández-Moreira, Hegira Ramírez, Nogueda-Torres B.Fuentes:scopusSynthesis and in silico ADME/Tox profiling studies of heterocyclic hybrids based on chloroquine scaffolds with potential antimalarial activity
ArticleAbstract: A series of heterocyclic chloroquine hybrids containing either a β-phenethylamine fragment or a 2-amPalabras claves:2-Aminoindane, Chloroquine, Hemozoin, MALARIA, β-PhenethylamineAutores:Ángel J.E., Charris J.E., Esteban Fernández-Moreira, Hegira Ramírez, Mijares M.R., Rodrigues J.R.Fuentes:scopusSynthesis of 5H-indeno[1,2-b]pyridine derivatives: Antiproliferative and antimetastatic activities against two human prostate cancer cell lines
ArticleAbstract: This study describes the direct synthesis of 2-amino-4-(phenylsubstituted)-5H-indeno[1,2-b]pyridine-Palabras claves:ANTICANCER, antimetastatic, Antiproliferative, indeno, prostate, pyridineAutores:Ángel J.E., Charris J.E., Charris K.E., Esteban Fernández-Moreira, Hegira Ramírez, Rodrigues J.R.Fuentes:scopusSynthesis of trans- and cis-2-acetyl-3-phenyl-3,3a,4,5-tetrahydro-2H-benzo[g] indazoles: evaluation as inhibitors of β-hematin formation
ArticleAbstract: Several trans- and cis-2-acetyl-3-(substituted-phenyl)-3,3a,4,5-tetrahydro-2H-benzo[g]indazole derivPalabras claves:Diastereomers, Hydrazine, Indazoles, MALARIA, Pyrazolines, Β-hematinAutores:Acosta M.E., Ángel J.E., Aparicio D.A., Charris J.E., Llovera L.J., Lobo G.M., Lola De Lima, Monasterios M.C., Sanchez J.L.Fuentes:scopusSynthesis, Leishmanicidal, Trypanocidal, Antiproliferative Assay and Apoptotic Induction of (2-Phenoxypyridin-3-yl)naphthalene-1(2H)-one Derivatives
ArticleAbstract: The coexistence of leishmaniasis, Chagas disease, and neoplasia in endemic areas has been extensivelPalabras claves:apoptosis, Cáncer, chalcone, leishmaniasis, TRYPANOSOMA CRUZIAutores:Ángel J.E., Blanco Z., Celis C., Charris J.E., de Sanctis J.B., Džubák P., Esteban Fernández-Moreira, García Y., Gurská S., Hajdůch M., Hegira Ramírez, Jhonny Correa-Abril, Martinez G.P., Mijares M.R., Mijoba A., Nahum Herrera, Serrano X., Yonathan De J. ParraFuentes:scopus