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Proceedings of the National Academy of Sciences of the United States of America(3)
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Commercial AHAS-inhibiting herbicides are promising drug leads for the treatment of human fungal pathogenic infections
ArticleAbstract: The increased prevalence of drug-resistant human pathogenic fungal diseases poses a major threat toPalabras claves:acetohydroxyacid synthase, Antifungal drug, Candida Albicans, Crystal structure, HerbicideAutores:Agnew-Francis K., Chua S.M.H., Fraser J.A., Guddat L.W., Lee Y.T., Lonhienne T., Low Y.S., Mario D. Garcia, Mario Daniel García, Nouwens A., Wang J.G., Williams C.M.Fuentes:googlescopusComprehensive understanding of acetohydroxyacid synthase inhibition by different herbicide families
ArticleAbstract: Five commercial herbicide families inhibit acetohydroxyacid synthase (AHAS, E.C. 2.2.1.6), which isPalabras claves:acetohydroxyacid synthase, Acetolactate synthase, Crystal structure, Herbicide, ThDPAutores:Guddat L.W., Lonhienne T., Mario D. Garcia, Mario Daniel García, Nouwens A.Fuentes:googlescopusCrystal Structure of the Commercial Herbicide, Amidosulfuron, in Complex with Arabidopsis thaliana Acetohydroxyacid Synthase
ArticleAbstract: Amidosulfuron (AS) is from the commercial sulfonylurea herbicide family. It is highly effective agaiPalabras claves:Enzyme, herbicides, Inhibition, interactions, weedsAutores:Cheng Y., Guddat L.W., Lonhienne T., Mario D. Garcia, Mario Daniel García, Schenk G., Williams C.M.Fuentes:googlescopusCrystal Structures of Staphylococcus aureus Ketol-Acid Reductoisomerase in Complex with Two Transition State Analogues that Have Biocidal Activity
ArticleAbstract: Ketol-acid reductoisomerase (KARI) is an NAD(P)H and Mg2+-dependent enzyme of the branched-chain amiPalabras claves:branched-chain amino acid biosynthesis, Drug Discovery, Herbicide, ketol-acid reductoisomerase, transition state analogueAutores:David A. Terán, Guddat L.W., Kandale A., Lv Y., Mario Daniel García, McGeary R.P., Patel K.M., Schembri M.A., Schenk G., Zheng S.Fuentes:scopusCrystal structure of plant acetohydroxyacid synthase, the target for several commercial herbicides
ArticleAbstract: Acetohydroxyacid synthase (AHAS, EC 2.2.1.6) is the first enzyme in the branched-chain amino acid biPalabras claves:acetohydroxyacid synthase, Acetolactate synthase, Herbicide, inhibitor, thiamine diphosphateAutores:Guddat L.W., Lonhienne T., Mario D. Garcia, Mario Daniel García, Wang J.G.Fuentes:googlescopusCrystal structures and inhibition of Trypanosoma brucei hypoxanthine-guanine phosphoribosyltransferase
ArticleAbstract: Human African Trypanosomiasis (HAT) is a life-threatening infectious disease caused by the protozoanPalabras claves:Autores:Česnek M., David A. Terán, Guddat L.W., Hocková D., Keough D.T., Naesens L., Zíková A.Fuentes:scopusCrystal structures of Trypanosoma brucei hypoxanthine – guanine – xanthine phosphoribosyltransferase in complex with IMP, GMP and XMP
ArticleAbstract: The 6-oxopurine phosphoribosyltransferases (PRTs) are drug targets for the treatment of parasitic diPalabras claves:6-oxopurine phosphoribosyltransferase, GMP, IMP, purine salvage, Trypanosoma brucei, XMPAutores:David A. Terán, Doleželová E., Guddat L.W., Hocková D., Keough D.T., Zíková A.Fuentes:scopusEvaluation of the Trypanosoma brucei 6-oxopurine salvage pathway as a potential target for drug discovery
ArticleAbstract: Due to toxicity and compliance issues and the emergence of resistance to current medications new druPalabras claves:Autores:David A. Terán, Doleželová E., Gahura O., Guddat L.W., Hocková D., Keough D.T., Kotrbová Z., Procházková M., Špaček P., Zíková A.Fuentes:scopusHERBICIDES THAT INHIBIT ACETOLACTATE SYNTHASE
ArticleAbstract: Herbicides are an essential pillar in modern agricultural practice. They are used to selectively redPalabras claves:Autores:Guddat L.W., Lonhienne T., Low Y.S., Mario Daniel GarcíaFuentes:scopusHigh Resolution Crystal Structures of the Acetohydroxyacid Synthase-Pyruvate Complex Provide New Insights into Its Catalytic Mechanism
ArticleAbstract: Acetohydroxyacid synthase (AHAS) is the first enzyme in the biosynthesis pathway of the branched-chaPalabras claves:acetohydroxyacid synthase, FAD, O 2, pyruvate, RedoxAutores:Fraser J.A., Guddat L.W., Harmer J., Lonhienne T., Mario Daniel García, Noble C., Williams C.M.Fuentes:scopus