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Comprehensive understanding of acetohydroxyacid synthase inhibition by different herbicide families
ArticleAbstract: Five commercial herbicide families inhibit acetohydroxyacid synthase (AHAS, E.C. 2.2.1.6), which isPalabras claves:acetohydroxyacid synthase, Acetolactate synthase, Crystal structure, Herbicide, ThDPAutores:Guddat L.W., Lonhienne T., Mario D. Garcia, Mario Daniel García, Nouwens A.Fuentes:googlescopusCrystal Structures of Staphylococcus aureus Ketol-Acid Reductoisomerase in Complex with Two Transition State Analogues that Have Biocidal Activity
ArticleAbstract: Ketol-acid reductoisomerase (KARI) is an NAD(P)H and Mg2+-dependent enzyme of the branched-chain amiPalabras claves:branched-chain amino acid biosynthesis, Drug Discovery, Herbicide, ketol-acid reductoisomerase, transition state analogueAutores:David A. Terán, Guddat L.W., Kandale A., Lv Y., Mario Daniel García, McGeary R.P., Patel K.M., Schembri M.A., Schenk G., Zheng S.Fuentes:scopusCrystal structures and inhibition of Trypanosoma brucei hypoxanthine-guanine phosphoribosyltransferase
ArticleAbstract: Human African Trypanosomiasis (HAT) is a life-threatening infectious disease caused by the protozoanPalabras claves:Autores:Česnek M., David A. Terán, Guddat L.W., Hocková D., Keough D.T., Naesens L., Zíková A.Fuentes:scopusEvaluation of the Trypanosoma brucei 6-oxopurine salvage pathway as a potential target for drug discovery
ArticleAbstract: Due to toxicity and compliance issues and the emergence of resistance to current medications new druPalabras claves:Autores:David A. Terán, Doleželová E., Gahura O., Guddat L.W., Hocková D., Keough D.T., Kotrbová Z., Procházková M., Špaček P., Zíková A.Fuentes:scopusTriazolopyrimidine herbicides are potent inhibitors of Aspergillus fumigatus acetohydroxyacid synthase and potential antifungal drug leads
ArticleAbstract: Aspergillus fumigatus is a fungal pathogen whose effects can be debilitating and potentially fatal iPalabras claves:Autores:Fraser J.A., Guddat L.W., Lonhienne T., Low Y.S., Mario D. Garcia, Mario Daniel García, Schenk G.Fuentes:googlescopusStructural insights into the mechanism of inhibition of AHAS by herbicides
ArticleAbstract: Acetohydroxyacid synthase (AHAS), the first enzyme in the branched amino acid biosynthesis pathway,Palabras claves:acetohydroxyacid synthase, Crystal structure, FAD, Herbicide, ThDPAutores:Guddat L.W., Lonhienne T., Mario D. Garcia, Mario Daniel García, Mobli M., Nouwens A., Pierens G.Fuentes:googlescopusStructures of fungal and plant acetohydroxyacid synthases
ArticleAbstract: Acetohydroxyacid synthase (AHAS), also known as acetolactate synthase, is a flavin adenine dinucleotPalabras claves:Autores:Brillault L., Croll T., Fraser J.A., Gao Y., Guddat L.W., Landsberg M.J., Lonhienne T., Low Y.S., Mario Daniel García, McGeary R.P., Rao Z., Schenk G., Wang Q., West N.P., Williams C.M.Fuentes:scopusThe 2.0 Å X-ray structure for yeast acetohydroxyacid synthase provides new insights into its cofactor and quaternary structure requirements
ArticleAbstract: Acetohydroxyacid synthase (AHAS) catalyzes the first step of branched-chain amino acid biosynthesis,Palabras claves:Autores:Fraser J.A., Guddat L.W., Lonhienne T., Mario D. Garcia, Mario Daniel García, Williams C.M.Fuentes:googlescopus