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Commercial AHAS-inhibiting herbicides are promising drug leads for the treatment of human fungal pathogenic infections
ArticleAbstract: The increased prevalence of drug-resistant human pathogenic fungal diseases poses a major threat toPalabras claves:acetohydroxyacid synthase, Antifungal drug, Candida Albicans, Crystal structure, HerbicideAutores:Agnew-Francis K., Chua S.M.H., Fraser J.A., Guddat L.W., Lee Y.T., Lonhienne T., Low Y.S., Mario D. Garcia, Mario Daniel García, Nouwens A., Wang J.G., Williams C.M.Fuentes:googlescopusComprehensive understanding of acetohydroxyacid synthase inhibition by different herbicide families
ArticleAbstract: Five commercial herbicide families inhibit acetohydroxyacid synthase (AHAS, E.C. 2.2.1.6), which isPalabras claves:acetohydroxyacid synthase, Acetolactate synthase, Crystal structure, Herbicide, ThDPAutores:Guddat L.W., Lonhienne T., Mario D. Garcia, Mario Daniel García, Nouwens A.Fuentes:googlescopusHERBICIDES THAT INHIBIT ACETOLACTATE SYNTHASE
ArticleAbstract: Herbicides are an essential pillar in modern agricultural practice. They are used to selectively redPalabras claves:Autores:Guddat L.W., Lonhienne T., Low Y.S., Mario Daniel GarcíaFuentes:scopusHigh Resolution Crystal Structures of the Acetohydroxyacid Synthase-Pyruvate Complex Provide New Insights into Its Catalytic Mechanism
ArticleAbstract: Acetohydroxyacid synthase (AHAS) is the first enzyme in the biosynthesis pathway of the branched-chaPalabras claves:acetohydroxyacid synthase, FAD, O 2, pyruvate, RedoxAutores:Fraser J.A., Guddat L.W., Harmer J., Lonhienne T., Mario Daniel García, Noble C., Williams C.M.Fuentes:scopusStructural basis of resistance to herbicides that target acetohydroxyacid synthase
ArticleAbstract: Acetohydroxyacid synthase (AHAS) is the target for more than 50 commercial herbicides; first appliedPalabras claves:Autores:Cheng Y., Guddat L.W., Hu S.H., Lonhienne T., Low Y.S., Mario D. Garcia, Mario Daniel García, Schenk G., Williams C.M.Fuentes:googlescopusStructural insights into the mechanism of inhibition of AHAS by herbicides
ArticleAbstract: Acetohydroxyacid synthase (AHAS), the first enzyme in the branched amino acid biosynthesis pathway,Palabras claves:acetohydroxyacid synthase, Crystal structure, FAD, Herbicide, ThDPAutores:Guddat L.W., Lonhienne T., Mario D. Garcia, Mario Daniel García, Mobli M., Nouwens A., Pierens G.Fuentes:googlescopus