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Proceedings of the National Academy of Sciences of the United States of America(3)
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Microorganismos, hongos y algas(4)
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scopus(9)
Commercial AHAS-inhibiting herbicides are promising drug leads for the treatment of human fungal pathogenic infections
ArticleAbstract: The increased prevalence of drug-resistant human pathogenic fungal diseases poses a major threat toPalabras claves:acetohydroxyacid synthase, Antifungal drug, Candida Albicans, Crystal structure, HerbicideAutores:Agnew-Francis K., Chua S.M.H., Fraser J.A., Guddat L.W., Lee Y.T., Lonhienne T., Low Y.S., Mario D. Garcia, Mario Daniel García, Nouwens A., Wang J.G., Williams C.M.Fuentes:googlescopusComprehensive understanding of acetohydroxyacid synthase inhibition by different herbicide families
ArticleAbstract: Five commercial herbicide families inhibit acetohydroxyacid synthase (AHAS, E.C. 2.2.1.6), which isPalabras claves:acetohydroxyacid synthase, Acetolactate synthase, Crystal structure, Herbicide, ThDPAutores:Guddat L.W., Lonhienne T., Mario D. Garcia, Mario Daniel García, Nouwens A.Fuentes:googlescopusCrystal Structure of the Commercial Herbicide, Amidosulfuron, in Complex with Arabidopsis thaliana Acetohydroxyacid Synthase
ArticleAbstract: Amidosulfuron (AS) is from the commercial sulfonylurea herbicide family. It is highly effective agaiPalabras claves:Enzyme, herbicides, Inhibition, interactions, weedsAutores:Cheng Y., Guddat L.W., Lonhienne T., Mario D. Garcia, Mario Daniel García, Schenk G., Williams C.M.Fuentes:googlescopusCrystal structure of plant acetohydroxyacid synthase, the target for several commercial herbicides
ArticleAbstract: Acetohydroxyacid synthase (AHAS, EC 2.2.1.6) is the first enzyme in the branched-chain amino acid biPalabras claves:acetohydroxyacid synthase, Acetolactate synthase, Herbicide, inhibitor, thiamine diphosphateAutores:Guddat L.W., Lonhienne T., Mario D. Garcia, Mario Daniel García, Wang J.G.Fuentes:googlescopusTriazolopyrimidine herbicides are potent inhibitors of Aspergillus fumigatus acetohydroxyacid synthase and potential antifungal drug leads
ArticleAbstract: Aspergillus fumigatus is a fungal pathogen whose effects can be debilitating and potentially fatal iPalabras claves:Autores:Fraser J.A., Guddat L.W., Lonhienne T., Low Y.S., Mario D. Garcia, Mario Daniel García, Schenk G.Fuentes:googlescopusStructural basis of resistance to herbicides that target acetohydroxyacid synthase
ArticleAbstract: Acetohydroxyacid synthase (AHAS) is the target for more than 50 commercial herbicides; first appliedPalabras claves:Autores:Cheng Y., Guddat L.W., Hu S.H., Lonhienne T., Low Y.S., Mario D. Garcia, Mario Daniel García, Schenk G., Williams C.M.Fuentes:googlescopusStructural insights into the mechanism of inhibition of AHAS by herbicides
ArticleAbstract: Acetohydroxyacid synthase (AHAS), the first enzyme in the branched amino acid biosynthesis pathway,Palabras claves:acetohydroxyacid synthase, Crystal structure, FAD, Herbicide, ThDPAutores:Guddat L.W., Lonhienne T., Mario D. Garcia, Mario Daniel García, Mobli M., Nouwens A., Pierens G.Fuentes:googlescopusThe 2.0 Å X-ray structure for yeast acetohydroxyacid synthase provides new insights into its cofactor and quaternary structure requirements
ArticleAbstract: Acetohydroxyacid synthase (AHAS) catalyzes the first step of branched-chain amino acid biosynthesis,Palabras claves:Autores:Fraser J.A., Guddat L.W., Lonhienne T., Mario D. Garcia, Mario Daniel García, Williams C.M.Fuentes:googlescopusThe role of a FAD cofactor in the regulation of acetohydroxyacid synthase by redox signaling molecules
ArticleAbstract: Acetohydroxyacid synthase (AHAS) catalyzes the first step of branched-chain amino acid (BCAA) biosynPalabras claves:Autores:Guddat L.W., Lonhienne T., Mario D. Garcia, Mario Daniel GarcíaFuentes:googlescopus