Mostrando 3 resultados de: 3
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Article(3)
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Proceedings of the National Academy of Sciences of the United States of America(2)
PLoS Neglected Tropical Diseases(1)
Commercial AHAS-inhibiting herbicides are promising drug leads for the treatment of human fungal pathogenic infections
ArticleAbstract: The increased prevalence of drug-resistant human pathogenic fungal diseases poses a major threat toPalabras claves:acetohydroxyacid synthase, Antifungal drug, Candida Albicans, Crystal structure, HerbicideAutores:Agnew-Francis K., Chua S.M.H., Fraser J.A., Guddat L.W., Lee Y.T., Lonhienne T., Low Y.S., Mario D. Garcia, Mario Daniel García, Nouwens A., Wang J.G., Williams C.M.Fuentes:googlescopusEvaluation of the Trypanosoma brucei 6-oxopurine salvage pathway as a potential target for drug discovery
ArticleAbstract: Due to toxicity and compliance issues and the emergence of resistance to current medications new druPalabras claves:Autores:David A. Terán, Doleželová E., Gahura O., Guddat L.W., Hocková D., Keough D.T., Kotrbová Z., Procházková M., Špaček P., Zíková A.Fuentes:scopusStructural insights into the mechanism of inhibition of AHAS by herbicides
ArticleAbstract: Acetohydroxyacid synthase (AHAS), the first enzyme in the branched amino acid biosynthesis pathway,Palabras claves:acetohydroxyacid synthase, Crystal structure, FAD, Herbicide, ThDPAutores:Guddat L.W., Lonhienne T., Mario D. Garcia, Mario Daniel García, Mobli M., Nouwens A., Pierens G.Fuentes:googlescopus