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scopus(14)
The marine sponge toxin agelasine B increases the intracellular Ca 2+ concentration and induces apoptosis in human breast cancer cells (MCF-7)
ArticleAbstract: Purpose: In search for new drugs derived from natural products for the possible treatment of cancer,Palabras claves:Agelasine B, calcium, Natural products, SERCA, ThapsigarginAutores:Alírica Isabel Suárez, Arvelo F.A., Benaím G., Chirino P., Colman L., Compagnone R.S., de Sanctis J.B., Dipolo R., Felibertt P., Galindo-Castro I., Mayora A., Pimentel A.A., Rojas H., Silva M.L., Sojo F.J.Fuentes:scopusThe natural diterpene ent-16β-17α-dihydroxykaurane down-regulates Bcl-2 by disruption of the Ap-2α/Rb transcription activating complex and induces E2F1 up-regulation in MCF-7 cells
ArticleAbstract: ent-Kauranes are diterpene-type compounds commonly found in most plant species, especially from thePalabras claves:AP-2α/Rb, apoptosis, BCL-2, E2F1, ent-16β-17α-Dihydroxykaurane (DHK), PUMAAutores:Alírica Isabel Suárez, Álvarez A., Alvaro Morales, Arvelo F.A., Compagnone R.S., Galindo-Castro I., Morales A.Fuentes:scopusStructure of highly substituted agarans from the red seaweeds Laurencia obtusa and Laurencia filiformis
ArticleAbstract: The water extracts from red seaweeds Laurencia obtusa and Laurencia filiformis comprise complex sulfPalabras claves:Agaran, Galactan structure, Laurencia, Red seaweed polysaccharide, Sulfated polysaccharideAutores:Alírica Isabel Suárez, Canelón D.J., Ciancia M., Compagnone R.S., Matulewicz M.Fuentes:scopusSynthesis and biological evaluation of caracasine acid derivatives
ArticleAbstract: A series of caracasine acid (1) derivatives were synthesized and evaluated for their in vitro cytotoPalabras claves:antibacterial, Antileishmanial, Antitrypanosomal, Caracasine acid, Cytotoxic activity, Ent-kaurane, SynthesisAutores:Alírica Isabel Suárez, Álvarez A., Arocha I., Chavez K., Compagnone R.S., Figarella K., Galindo-Castro I., Marsiccobetre S., Orsini G., Taddei A., Tillett S., Triviño J.Fuentes:scopusBiflavonoids from Podocalyx loranthoides
ArticleAbstract: Analysis of the ethyl acetate extract of the aerials parts of Podocalyx loranthoides led to the isolPalabras claves:Podocalyx loranthoides, Podocarpusflavone A, PutraflavoneAutores:Alírica Isabel Suárez, Compagnone R.S., Delle Monache F., Diaz M B.Fuentes:scopusCrotofolane diterpenoids from Croton caracasanus
ArticleAbstract: Four new crotofolane-type diterpenoids, crotocarasin (A-D) (1-4), together with the known crotofolinPalabras claves:Crotofolanes, Croton caracasanus Pittier, Diterpenoids, EuphorbiaceaeAutores:Alírica Isabel Suárez, Bricẽo A., Chavez K., Compagnone R.S., Gonzalez T., Landaeta C., Riina R., Soscun H.J., Squitieri E., Teresa GonzálezFuentes:scopusCytotoxic activity of seco-entkaurenes from Croton caracasana on human cancer cell lines
ArticleAbstract: In the course of searching for bioactive compounds from Croton species from Venezuela, two seco-entkPalabras claves:Croton caracasana, Cytotoxic, Euphorbiaceae, seco-entkaurenesAutores:Alírica Isabel Suárez, Arvelo F.A., Chavez K., Compagnone R.S., de Sanctis J.B., Mateu E., Mijares M.R., Muñoz A., Sojo F.J.Fuentes:scopusCytotoxic and proapoptotic activity of ent-16β-17α- dihydroxykaurane on human mammary carcinoma cell line MCF-7
ArticleAbstract: Here we describe the cytotoxic and proapoptotic effect of an ent-kaurane (ent-16β-17α-dihydroxykauraPalabras claves:Anticancer agents, apoptosis, BCL2, Cytotoxic activity, Ent-kaurane, Telomerase activityAutores:Alírica Isabel Suárez, Alvaro Morales, Arvelo F.A., Compagnone R.S., Galindo-Castro I., Luis Ramírez J., Mendoza R., Morales A., Pérez P.Fuentes:scopusCytotoxic effects of fisturalin-3 and 11-Deoxyfisturalin-3 on Jurkat and U937 cell lines
ArticleAbstract: Background. Fisturalines are bromotyrosine compounds isolated from marine sponges. Previous studiesPalabras claves:11-deoxyfistularin-3, Aplysina fistularis, Bromotyrosine, Cancer, Fistularin-3, Leukemia, quercetinAutores:Alírica Isabel Suárez, Avila R., Barroeta A., Chirinos P., Compagnone R.S., de Sanctis J.B., Martinez G.P., Mijares M.R., Ochoa M.Fuentes:scopusCaracasine acid, an ent-3,4-seco-kaurene, promotes apoptosis and cell differentiation through NFkB signal pathway inhibition in leukemia cells.
ArticleAbstract: Caracasine acid (CA) is an ent-3,4-seco-kaurene isolated from the plant Croton micans. Decreased canPalabras claves:Annexin V, apoptosis, Cancer, Caracasine acid, Croton, Kaurene compounds, Leukemia, NF-κBAutores:Alírica Isabel Suárez, Chavez K., Chirinos P., Compagnone R.S., de Sanctis J.B., Martinez G.P., Mijares M.R.Fuentes:scopus