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Cytotoxic and proapoptotic activity of ent-16β-17α- dihydroxykaurane on human mammary carcinoma cell line MCF-7
ArticleAbstract: Here we describe the cytotoxic and proapoptotic effect of an ent-kaurane (ent-16β-17α-dihydroxykauraPalabras claves:Anticancer agents, apoptosis, BCL2, Cytotoxic activity, Ent-kaurane, Telomerase activityAutores:Alírica Isabel Suárez, Arvelo F.A., Compagnone R.S., Galindo-Castro I., Luis Ramírez J., Mendoza R., Morales A., Pérez P.Fuentes:scopusCaracasine acid, an ent-3,4-seco-kaurene, promotes apoptosis and cell differentiation through NFkB signal pathway inhibition in leukemia cells.
ArticleAbstract: Caracasine acid (CA) is an ent-3,4-seco-kaurene isolated from the plant Croton micans. Decreased canPalabras claves:Annexin-V, apoptosis, Cáncer, Caracasine acid, Croton, Kaurene compounds, Leukemia, NF-κBAutores:Alírica Isabel Suárez, Chavez K., Chirinos P., Compagnone R.S., de Sanctis J.B., Martinez G.P., Mijares M.R.Fuentes:scopusThe natural diterpene ent-16β-17α-dihydroxykaurane down-regulates Bcl-2 by disruption of the Ap-2α/Rb transcription activating complex and induces E2F1 up-regulation in MCF-7 cells
ArticleAbstract: ent-Kauranes are diterpene-type compounds commonly found in most plant species, especially from thePalabras claves:AP-2α/Rb, apoptosis, BCL-2, E2F1, ent-16β-17α-Dihydroxykaurane (DHK), PUMAAutores:Alírica Isabel Suárez, Álvarez A., Arvelo F.A., Compagnone R.S., Galindo-Castro I., Morales A.Fuentes:scopus