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Clinical applications of pharmacogenomics
ArticleAbstract: Pharmacogenomics is an emergent field aimed at tailoring pharmacological therapy. Genetic polymorphiPalabras claves:genetic, pharmacogenetics, Pharmacogenomic variants, pharmacokinetics, polymorphismsAutores:Cayún J.P., Escalante P., Fausto Zaruma-Torres, Gallegos B., Lares-Asseff I., Meneses F., Miranda C., Quiñones L.A., Roco A.M., Varela N.M.Fuentes:scopusA New Insight for the Identification of Oncogenic Variants in Breast and Prostate Cancers in Diverse Human Populations, With a Focus on Latinos
ArticleAbstract: Background: Breast cancer (BRCA) and prostate cancer (PRCA) are the most commonly diagnosed cancer tPalabras claves:Breast, latino population, oncogenic variants, precision oncology, prostateAutores:Acevedo C., Andrés López-Cortés, Isaac Armendáriz-Castillo, P. Guevara-Ramírez, Quiñones L.A., Santiago Xavier Guerrero, Varela N.M., Zambrano T.Fuentes:scopusGenetic polymorphisms associated to folate transport as pbkp_redictors of increased risk for acute lymphoblastic leukemia in Mexican children
ArticleAbstract: Acute lymphoblastic leukemia (ALL) is a frequent neoplasia occurring in children. The most commonlyPalabras claves:Acute lymphoblastic leukemia, Folate transporters, Genetic Polymorphisms, methotrexate, Molecular epidemiologyAutores:Fausto Zaruma-Torres, Galaviz-Hernandez C., Lares-Asseff I., Lima A., Loera-Castañeda V., María Cristina Arias-Peláez, Quiñones L.A., Reyes-Espinoza A., Reyes-López M., Sosa-Macías M.G.Fuentes:scopusEditorial: Pharmacogenetics and Pharmacogenomics in Latin America: Ethnic Variability, New Insights in Advances and Perspectives: A RELIVAF-CYTED Initiative
OtherAbstract:Palabras claves:CYTED, Latin America, pharmacogenetics, Pharmacogenomics, Precision MedicineAutores:Andrés López-Cortés, Esperón P., Lazarowski A., Martínez M.F., Quiñones L.A., Redal M.A., Varela N.M.Fuentes:googlescopusIn silico Analyses of Immune System Protein Interactome Network, Single-Cell RNA Sequencing of Human Tissues, and Artificial Neural Networks Reveal Potential Therapeutic Targets for Drug Repurposing Against COVID-19
ArticleAbstract: Background: There is pressing urgency to identify therapeutic targets and drugs that allow treatingPalabras claves:artificial neural networks, covid-19, drug repurposing, Immune system, single-cell RNA sequencingAutores:Adriana Granizo-Martínez, Alejandro Cabrera-Andrade, Ana Karina Zambrano, Ana María Gómez-Jaramillo, Andreina Quevedo, Andrés López-Cortés, Ángela León-Cáceres, Carlos Barba-Ostria, Cesar Paz-y-Miño, Cevallos-Robalino D., Eduardo Tejera, Esteban Ortiz-Prado, Jennyfer M. García-Cárdenas, Jhommara Bautista, Katherine Simbaña-Rivera, Lourdes Puig San Andrés, Moreno S., Munteanu C.R., Nikolaos C. Kyriakidis, P. Guevara-Ramírez, Pérez-M G., Proaño-Castro C., Quiñones L.A., Santiago Xavier Guerrero, Varela N.M., Yunierkis Perez-CastilloFuentes:scopusPerception of the usefulness of drug/gene pairs and barriers for pharmacogenomics in latin America
ReviewAbstract: Pharmacogenetics and Pharmacogenomics areas are currently emerging fields focused to manage pharmacoPalabras claves:adverse drug reactions, Biomarkers, Clinical recommendations, Clinical relevance, PharmacogenomicsAutores:Agúndez J.A.G., Andrés López-Cortés, Cáceres D.D., Castañeda-Hernández G., Cayún J.P., Chiurillo M.A., De Guerra D.C., Encina G., Enrique Terán, Eslava-Schmalbach J., Estévez-Carrizo F.E., García-Martin E., Herrera L., Isaza C.A., Lares-Assef I., Laróvere L., Lavanderos M.A., López M.L., Magno L.A., Morales J.E., Quiñones L.A., Redal M.A., Roco A.M., Rodeiro I., Soria N.W.Fuentes:googlescopusPharmacogenomics, biomarker network, and allele frequencies in colorectal cancer
ReviewAbstract: Colorectal cancer is one of the leading causes of cancer death worldwide. Over the last decades, sevPalabras claves:Autores:Andrés López-Cortés, Ángela León-Cáceres, Cayún J.P., Cesar Paz-y-Miño, Dámaris P. Intriago-Baldeón, Gabriela Fernanda Jaramillo-Koupermann, Isaac Armendáriz-Castillo, Jennyfer García, Jennyfer M. García-Cárdenas, P. Guevara-Ramírez, Paola E. Leone, Quiñones L.A., Santiago Xavier Guerrero, Soria N.W.Fuentes:googlescopusPulmonary Inflammatory Response in Lethal COVID-19 Reveals Potential Therapeutic Targets and Drugs in Phases III/IV Clinical Trials
ArticleAbstract: Background: It is imperative to identify drugs that allow treating symptoms of severe COVID-19. RespPalabras claves:clinical trials, drugs, lethal COVID-19, pulmonary inflammatory response, single nucleus RNA sequencingAutores:Alejandro Cabrera-Andrade, Álvaro A. Pérez-Meza, Ana María Gómez-Jaramillo, Andrea Abad-Sojos, Andrea V. Jácome, Andrés López-Cortés, Andy Pérez-Villa, Ángela León-Cáceres, Antonella Vera-Guapi, Ariana León-Sosa, Cevallos-Robalino D., Echeverría-Garcés G., Esteban Ortiz-Prado, Estefanía Abarca, Fernanda Arias-Erazo, Isaac Armendáriz-Castillo, Jennyfer M. García-Cárdenas, Jhommara Bautista, Katherine Simbaña-Rivera, Lourdes Puig San Andrés, Luis Fuenmayor-González, Morillo A., Nieto-Jaramillo K., Nikolaos C. Kyriakidis, P. Guevara-Ramírez, Quiñones L.A., Ramos-Medina M.J., Santiago Xavier Guerrero, Verónica YumicebaFuentes:scopusState of art of cancer pharmacogenomics in Latin American populations
ReviewAbstract: Over the past decades, several studies have shown that tumor-related somatic and germline alterationPalabras claves:Cáncer, Latin America, pharmacogenetics, Pharmacogenomics, Precision Medicine, Single nucleotide polymorphismAutores:Alvarado A.T., Andrés López-Cortés, Quiñones L.A., Redal M.A., Santiago Xavier GuerreroFuentes:googlescopus