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Generation of a highly sensitive reporter plasmid for the detection of the transcripcional response to hypoxia
ArticleAbstract: Decreased oxygen supply to the tissues at both systemic and local level induces a genic program whicPalabras claves:HIF-1α, Hypoxia, transcription factorsAutores:Alfranca A., Aragonés J., Manuel Ortiz de Landázuri, Temes E., Vara A.Fuentes:scopusEvidence for the Involvement of Diacylglycerol Kinase in the Activation of Hypoxia-inducible Transcription Factor 1 by Low Oxygen Tension
ArticleAbstract: Hypoxia-inducible factor 1 (HIF-1) induces a gene expression program essential for the cellular adapPalabras claves:Autores:Alfranca A., Aragonés J., Jones D.R., Manuel Ortiz de Landázuri, Martin-Puig S., Mérida I., San Juan M.A., Vara A., Vidal F.Fuentes:scopusLack of evidence for the involvement of the phosphoinositide 3-kinase/Akt pathway in the activation of hypoxia-inducible factors by low oxygen tension
ArticleAbstract: Hypoxia-inducible factors (HIF) belong to an evolutionary conserved family of transcription factors,Palabras claves:Autores:Alfranca A., Álvarez-Tejado M., Aragonés J., Manuel Ortiz de Landázuri, Peso L.D., Vara A.Fuentes:scopusTranscriptional Up-Regulation of Intracellular Adhesion Molecule-1 in Human Endothelial Cells by the Antioxidant Pyrrolidine Dithiocarbamate Involves the Activation of Activating Protein-1
ArticleAbstract: The redox status of the cell plays an essential role in regulating signal transduction, transcriptioPalabras claves:Autores:Alfranca A., Castellanos M.C., Esteban M.A., Manuel Ortiz de Landázuri, Muñoz C., Redondo J.M., Vara A.Fuentes:scopusUp-regulation of vascular endothelial growth factor receptor Flt-1 after endothelial denudation: Role of transcription factor Egr-1
ArticleAbstract: Vascular endothelial growth factor (VEGF) is highly expressed in vascular remodeling processes and aPalabras claves:Autores:Alfranca A., Aragonés J., Manuel Ortiz de Landázuri, Vidal F.Fuentes:scopusc-Jun and hypoxia-inducible factor 1 functionally cooperate in hypoxia-induced gene transcription
ArticleAbstract: Under low-oxygen conditions, cells develop an adaptive program that leads to the induction of severaPalabras claves:Autores:Alfranca A., Aragonés J., Gutiérrez M.D., Manuel Ortiz de Landázuri, Vara A., Vidal F.Fuentes:scopusRegulation of endothelial cell motility by complexes of retraspan molecules CD81/TAPA-1 and CD151/PETA-3 with α3β1 integrin localized at endothelial lateral junctions
ArticleAbstract: Cell-to-cell junction structures play a key role in cell growth rate control and cell polarization.Palabras claves:Autores:Alfranca A., Ashman L.K., Cabañas C., Manuel Ortiz de Landázuri, Marazuela M., Sánchez‐Madrid F., Tejedor R., Ursa M.A., Yáñez-Mó M.Fuentes:scopusPyrrolidine dithiocarbamate inhibits the production of interleukin-6, interleukin-8, and granulocyte-macrophage colony-stimulating factor by human endothelial cells in response to inflammatory mediators: Modulation of NF- κB and AP-1 transcription factors activity
ArticleAbstract: Endothelial cells (EC) play a key role in the inflammatory response, both by the production of proinPalabras claves:Autores:Alfranca A., Aragonés J., Castellanos M.D.C., Manuel Ortiz de Landázuri, Muñoz C., Pascual-Salcedo D., Redondo J.M., Vara A.Fuentes:scopus