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Diversity and bias through receptor-receptor interactions in GPCR heteroreceptor complexes. Focus on examples from dopamine D2 receptor heteromerization
ReviewAbstract: Allosteric receptor-receptor interactions in GPCR heteromers appeared to introduce an intermolecularPalabras claves:allosteric modulation, Biased recognition, Biased signaling, G protein-coupled receptor, Heterodimerization, Receptor diversity, Receptor heterodimers, Receptor-receptor interactionsAutores:Agnati L.F., Borroto-Escuela D.O., Díaz-Cabiale Z., Ferraro L., Filip M., Fuxe K., Garriga P., Tanganelli S., Tarakanov A.O., W. Romero-FernandezFuentes:scopusDopamine D1 and D2 receptor immunoreactivities in the arcuate-median eminence complex and their link to the tubero-infundibular dopamine neurons
ArticleAbstract: Dopamine D1 and D2 receptor immunohistochemistry and Golgi techniques were used to study the structuPalabras claves:Arcuate-median eminence complex, Dopamine D1 and D2 receptors, Dopamine receptor colocalization, Luteinizing hormone releasing hormone, Tubero-infundibular dopamine neurons, Volume transmissionAutores:Agnati L.F., Borroto-Escuela D.O., Di Palma M., Fuxe K., Larriva Sahd J., Narváez M., Vargas-Barroso V., W. Romero-FernandezFuentes:scopusDopamine D2 heteroreceptor complexes and their receptor-receptor interactions in ventral striatum: Novel targets for antipsychotic drugs
Book PartAbstract: This review is focused on the D2 heteroreceptor complexes within the ventral striatum with their recPalabras claves:D2 receptors, Heteroreceptor complexes, Receptor-receptor interactions, Schizophrenia, Ventral striatumAutores:Agnati L.F., Borroto-Escuela D.O., Di Palma M., Ferraro L., Fuxe K., Pérez-Alea M., Tanganelli S., Tarakanov A.O., W. Romero-FernandezFuentes:scopusMoonlighting proteins and protein-protein interactions as neurotherapeutic targets in the G protein-coupled receptor field
ReviewAbstract: There is serious interest in understanding the dynamics of the receptor-receptor and receptor-proteiPalabras claves:G protein-coupled receptors, Heterodimerization, moonlighting, neuropsychiatric disorders, neurotherapeutic targets, receptorreceptor interactionsAutores:Agnati L.F., Borroto-Escuela D.O., Ciruela F., Fuxe K., Palkovits M., Tarakanov A.O., W. Romero-FernandezFuentes:scopusHallucinogenic 5-HT2AR agonists LSD and DOI enhance dopamine D2R protomer recognition and signaling of D2-5-HT2A heteroreceptor complexes
ArticleAbstract: Dopamine D2LR-serotonin 5-HT2AR heteromers were demonstrated in HEK293 cells after cotransfection ofPalabras claves:2,5-Dimethoxy-4-iodoamphetamine, allosteric modulation, Antipsychotic drugs, dopamine D2 receptor, G-protein-coupled receptors, Heterodimerization, Heteroreceptor complexes, Lysergic acid diethylamide, Receptor-receptor interactions, Serotonin 5-HT2A receptorAutores:Agnati L.F., Borroto-Escuela D.O., Fuxe K., Narváez M., Oflijan J., W. Romero-FernandezFuentes:scopusThe G protein-coupled receptor heterodimer network (GPCR-HetNet) and its hub components
ArticleAbstract: G protein-coupled receptors (GPCRs) oligomerization has emerged as a vital characteristic of receptoPalabras claves:Architecture, clusters, dimerization, G protein-coupled receptors, Heterodimerization, Heteromers, Hubs, network, Oligomerization, Receptor-receptor interactionsAutores:Agnati L.F., Borroto-Escuela D.O., Brito I., Di Palma M., Duchou J., Fuxe K., Guidolin D., Oflijan J., Rivera A., Skieterska K., Suárez-Boomgaard D., Van Craenenbroeck K., W. Romero-FernandezFuentes:scopus